Varaico: Literature-Extracted Genetic Variants

Gene:NR1I2
Variant:p.T57A
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NR1I2

NM_003889.4:p.T57A

Associated Papers

Nuclear receptor phosphorylation in xenobiotic signal transduction.

Negishi M et al.

The Journal of Biological Chemistry, 2020

Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.

Sugatani J et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2012

A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.

Lichti-Kaiser K et al.

The Journal of Pharmacology and Experimental Therapeutics, 2009

A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor.

Pondugula SR et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."