Associated Papers
A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR.
Rana M et al.
Biochimica Et Biophysica Acta, 2016
Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.
Banerjee M et al.
Biochemical Pharmacology, 2016
Role of pregnane X receptor in chemotherapeutic treatment.
Zhuo W et al.
Cancer Chemotherapy and Pharmacology, 2014
Genetic variability of PXR in Saudi Arabians.
Al-Dosari MS et al.
Biochemical Genetics, 2013
Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes.
Yang J et al.
Toxicology Letters, 2010
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
Zhang B et al.
Pharmacogenomics, 2008
Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy.
Owen BM et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2008
Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations.
Wang XD et al.
Pharmacology, 2008
Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.
Lim YP et al.
Pharmacogenetics and Genomics, 2007
Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects.
Lim YP et al.
Pharmacogenetics and Genomics, 2005
[Single nucleotide polymorphisms of growth hormone receptor gene in Chinese Han ethnic population].
Zhou J et al.
Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, 2004
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2004
Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations.
Koyano S et al.
Drug Metabolism and Pharmacokinetics, 2002
Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.
Meyer zu Schwabedissen HE et al.
Molecular Pharmaceutics, 0