Associated Papers
Pregnane X receptor (PXR/NR1I2): linking drug metabolism, bile acid detoxification, and cholesterol homeostasis.
Ganamurali N et al.
Drug Metabolism Reviews, 2026
Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity.
Petros Z et al.
Scientific Reports, 2022
Differential Effects of Components in Artemisia annua Extract on the Induction of Drug-Metabolizing Enzyme Expression Mediated by Nuclear Receptors.
Zhang X et al.
Planta Medica, 2020
Steroid-resistant nephrotic syndrome: pharmacogenetics and epigenetic points and views.
Hejazian SM et al.
Expert Review of Clinical Pharmacology, 2020
A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR.
Rana M et al.
Biochimica Et Biophysica Acta, 2016
Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.
Banerjee M et al.
Biochemical Pharmacology, 2016
Role of pregnane X receptor in chemotherapeutic treatment.
Zhuo W et al.
Cancer Chemotherapy and Pharmacology, 2014
Genetic variability of PXR in Saudi Arabians.
Al-Dosari MS et al.
Biochemical Genetics, 2013
Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.
Klein K et al.
Frontiers in Genetics, 2013
PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients.
Sandanaraj E et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2008
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
Zhang B et al.
Pharmacogenomics, 2008
Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy.
Owen BM et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2008
Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations.
Wang XD et al.
Pharmacology, 2008
Identification of NR1I2 genetic variation using resequencing.
King CR et al.
European Journal of Clinical Pharmacology, 2007
Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.
Lim YP et al.
Pharmacogenetics and Genomics, 2007
Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects.
Lim YP et al.
Pharmacogenetics and Genomics, 2005
[Single nucleotide polymorphisms of growth hormone receptor gene in Chinese Han ethnic population].
Zhou J et al.
Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, 2004
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2004
Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.
Meyer zu Schwabedissen HE et al.
Molecular Pharmaceutics, 0