Associated Papers
Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction-associated steatohepatitis in mice.
Basaly V et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2025
Physiological Functions and Pathological Roles of PXR.
Ikeda K et al.
Journal of the Endocrine Society, 2025
Insights of direct and indirect regulation of PXR through phosphorylation in fatty liver disease.
Basaly V et al.
Molecular Pharmacology, 2025
Mice blocking Ser347 phosphorylation of pregnane x receptor develop hepatic fasting-induced steatosis and hypertriglyceridemia.
Yokobori K et al.
Biochemical and Biophysical Research Communications, 2022
PXR phosphorylated at Ser350 transduces a glucose signal to repress the estrogen sulfotransferase gene in human liver cells and fasting signal in mouse livers.
Hu H et al.
Biochemical Pharmacology, 2020
Select a paper to view details