Associated Papers
Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction-associated steatohepatitis in mice.
Basaly V et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2025
Insights of direct and indirect regulation of PXR through phosphorylation in fatty liver disease.
Basaly V et al.
Molecular Pharmacology, 2025
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
Qin M et al.
Cells, 2022
Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
Gotoh S et al.
Cellular Signalling, 2017
Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo.
Wang YM et al.
Biochemical Pharmacology, 2015
Identification and characterization of phosphorylation sites within the pregnane X receptor protein.
Elias A et al.
Biochemical Pharmacology, 2014
Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation.
Sivertsson L et al.
Molecular Pharmacology, 2013
Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.
Sugatani J et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2012
A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.
Lichti-Kaiser K et al.
The Journal of Pharmacology and Experimental Therapeutics, 2009
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