Associated Papers
Unique autosomal recessive variant of palmoplantar keratoderma associated with hearing loss not caused by known mutations.
Hegazi MA et al.
Anais Brasileiros De Dermatologia, 2017
A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR.
Rana M et al.
Biochimica Et Biophysica Acta, 2016
Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.
Banerjee M et al.
Biochemical Pharmacology, 2016
Role of pregnane X receptor in chemotherapeutic treatment.
Zhuo W et al.
Cancer Chemotherapy and Pharmacology, 2014
The effect of fetal androgen metabolism-related gene variants on external genitalia virilization in congenital adrenal hyperplasia.
Kaupert LC et al.
Clinical Genetics, 2013
Pregnane X receptor polymorphisms associated with human diseases.
Kotta-Loizou I et al.
Expert Opinion on Therapeutic Targets, 2013
Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.
Klein K et al.
Frontiers in Genetics, 2013
Frequency of genetic polymorphisms of PXR gene in the Brazilian population.
Moreira RP et al.
Clinics (sao Paulo, Brazil), 2011
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.
Zhang B et al.
Pharmacogenomics, 2008
Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy.
Owen BM et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2008
Identification of NR1I2 genetic variation using resequencing.
King CR et al.
European Journal of Clinical Pharmacology, 2007
Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.
Lim YP et al.
Pharmacogenetics and Genomics, 2007
Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects.
Lim YP et al.
Pharmacogenetics and Genomics, 2005
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2004
Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.
Hustert E et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2001
Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.
Meyer zu Schwabedissen HE et al.
Molecular Pharmaceutics, 0