Associated Papers
The multimerization pathway of the glucocorticoid receptor.
Alegre-Martí A et al.
Nucleic Acids Research, 2025
Functional and Structural Impact of Deleterious Missense Single Nucleotide Polymorphisms in the NR3C1, CYP3A5, and TNF-α Genes: An In Silico Analysis.
Ramayanam NR et al.
Biomolecules, 2022
Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation.
Sciarrillo R et al.
Cancers, 2020
Deciphering the structural basis for glucocorticoid resistance caused by missense mutations in the ligand binding domain of glucocorticoid receptor.
Monteiro LLS et al.
Journal of Molecular Graphics & Modelling, 2019
Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxide.
Miller AL et al.
Plos One, 2017
Comprehensive overview of the structure and regulation of the glucocorticoid receptor.
Vandevyver S et al.
Endocrine Reviews, 2014
Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance.
Ramamoorthy S et al.
Endocrine Development, 2013
The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1 gene in patients with bronchial asthma.
Panek M et al.
International Journal of Molecular Medicine, 2012
Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor.
Schmidt S et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2006
Loss of heterozygosity and somatic mutations of the glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course.
Irving JA et al.
Cancer Research, 2005
Genetic variations in the glucocorticoid receptor gene are not related to glucocorticoid resistance in childhood acute lymphoblastic leukemia.
Tissing WJ et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2005
The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor.
Yoshikawa N et al.
Molecular Endocrinology (baltimore, Md.), 2005
Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cells.
Riml S et al.
Cell Death and Differentiation, 2004
Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms.
Bray PJ et al.
Human Mutation, 2003
Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.
Bledsoe RK et al.
Cell, 2002
Glucocorticoid receptor variants: clinical implications.
DeRijk RH et al.
The Journal of Steroid Biochemistry and Molecular Biology, 2002
Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophrenia.
Feng J et al.
American Journal of Medical Genetics, 2000
Glucocorticoid receptor gene mutations in leukemic cells acquired in vitro and in vivo.
Hillmann AG et al.
Cancer Research, 2000
Nuclear receptors: structure, function and involvement in disease.
Tenbaum S et al.
The International Journal of Biochemistry & Cell Biology, 1997
Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines.
Hala M et al.
International Journal of Cancer, 1996
Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.
Geley S et al.
Cancer Research, 1996
Glucocorticoid resistant syndromes--molecular basis and clinical presentations.
Brönnegård M et al.
Journal of Neuroendocrinology, 1996
Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line.
Strasser-Wozak EM et al.
Cancer Research, 1995