Varaico: Literature-Extracted Genetic Variants

Gene:NR3C1
Variant:p.C736S
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NR3C1

NM_000176.3:p.C736S

Associated Papers

The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism.

Kauppi B et al.

The Journal of Biological Chemistry, 2003

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.

Bledsoe RK et al.

Cell, 2002

Identification of single amino acid substitutions of Cys-736 that affect the steroid-binding affinity and specificity of the glucocorticoid receptor using phenotypic screening in yeast.

Lind U et al.

Molecular Endocrinology (baltimore, Md.), 1996

Glucocorticoid resistant syndromes--molecular basis and clinical presentations.

Brönnegård M et al.

Journal of Neuroendocrinology, 1996

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."