Varaico: Literature-Extracted Genetic Variants

Gene:NR3C1
Variant:p.V571M
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NR3C1

NM_000176.3:p.V571M

Associated Papers

Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.

Postel S et al.

Nature Structural & Molecular Biology, 2023

Molecular mechanism of allosteric communication in the human PPARalpha-RXRalpha heterodimer.

Venäläinen T et al.

Proteins, 2010

Probing the functional link between androgen receptor coactivator and ligand-binding sites in prostate cancer and androgen insensitivity.

He B et al.

The Journal of Biological Chemistry, 2006

Glucocorticoid receptor point mutation V571M facilitates coactivator and ligand binding by structural rearrangement and stabilization.

Carlsson P et al.

Molecular Endocrinology (baltimore, Md.), 2005

Valine 571 functions as a regional organizer in programming the glucocorticoid receptor for differential binding of glucocorticoids and mineralocorticoids.

Lind U et al.

The Journal of Biological Chemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."