Varaico: Literature-Extracted Genetic Variants

Gene:NRAS
Variant:p.K117R
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NRAS

NM_002524.5:p.K117R

Associated Papers

Clinical outcomes of genomically guided trametinib monotherapy across cancer types: results from the IMPRESS-Norway trial.

Slørdahl KS et al.

Acta Oncologica (stockholm, Sweden), 2026

41664938 (PubMed )
Supplement: AO-65-45086-s1.pdf

Genetic alterations affect immune contexture of non-small cell lung cancer: Ukrainian study.

Kozakov D et al.

Frontiers in Medicine, 2025

Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma.

Wen Y et al.

Nature Communications, 2024

39572526 (PubMed )
Supplement: 41467_2024_54140_MOESM1_ESM.pdf

Computational Exploration of Single-Nucleotide Polymorphisms in the Human hRAS Gene: Implications and Insights.

Dakshitha S et al.

Cureus, 2024

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Antić Ž et al.

Haematologica, 2021

Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma.

Frontzek F et al.

Nature Communications, 2021

34465776 (PubMed )
Supplement: 41467_2021_25405_MOESM9_ESM.xlsx › Targeted_resequencing_results

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

Loree JM et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2021

Mutational spectrum and classification of novel mutations in patients with metastatic gastrointestinal stromal tumours.

Bombac A et al.

International Journal of Oncology, 2020

32236636 (PubMed )
Supplement: Supplementary_Data.pdf

Costello syndrome: Clinical phenotype, genotype, and management guidelines.

Gripp KW et al.

American Journal of Medical Genetics. Part A, 2019

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers.

Hänninen UA et al.

British Journal of Cancer, 2019

30894686 (PubMed )
Supplement: 41416_2019_427_MOESM4_ESM.xlsx › Sheet1

Analysis of KRAS, NRAS, BRAF, and PIK3CA mutations could predict metastases in colorectal cancer: A preliminary study.

Wojas-Krawczyk K et al.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 2019

The modular network structure of the mutational landscape of Acute Myeloid Leukemia.

Ibáñez M et al.

Plos One, 2018

30303964 (PubMed )
Supplement: pone.0202926.s006.pdf

Prevalence of NRAS, PTEN and AKT1 gene mutations in the central nervous system metastases of non-small cell lung cancer.

Nicoś M et al.

Brain Tumor Pathology, 2017

Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics.

Magliacane G et al.

Oncotarget, 2015

Ras in cancer and developmental diseases.

Fernández-Medarde A et al.

Genes & Cancer, 2011

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.

Rauen KA et al.

American Journal of Medical Genetics. Part A, 2010

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders.

Aoki Y et al.

Human Mutation, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."