Varaico: Literature-Extracted Genetic Variants

Gene:NRAS
Variant:p.R68S
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NRAS

NM_002524.5:p.R68S

Associated Papers

Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia.

Chow RD et al.

Blood Advances, 2025

39938015 (PubMed )
Supplement: BLOODA_ADV-2024-015149-mmc2.xlsx › S2

Early drivers of clonal hematopoiesis shape the evolutionary trajectories of de novo acute myeloid leukemia.

Chow RD et al.

Medrxiv : the Preprint Server for Health Sciences, 2024

39252918 (PubMed )
Supplement: media-1.xlsx › S1

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.

Holderfield M et al.

Nature, 2024

38589574 (PubMed )
Supplement: 41586_2024_7205_MOESM5_ESM.xlsx › ED_Fig_10

Molecular pathways, resistance mechanisms and targeted interventions in non-small-cell lung cancer.

Wang Z et al.

Molecular Biomedicine, 2022

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

Weiss A et al.

Cancer Discovery, 2022

35404998 (PubMed )
Supplement: cd-22-0158_supplementary_tables_suppst1-st7.docx

Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance.

Reita D et al.

Cancers, 2022

The path to the clinic: a comprehensive review on direct KRASG12C inhibitors.

Kwan AK et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2022

Anticancer drug resistance: An update and perspective.

Nussinov R et al.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 2021

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

Loree JM et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2021

Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutations.

Tripathi S et al.

Bioinformatics (oxford, England), 2021

33226070 (PubMed )
Supplement: btaa972_supplementary_data.zip › RAS_Manuscript_RMarkdown.tar.gz › RAS_Manuscript1.Revised › RAS_Variants_Scores.xlsx › Sheet1

Longitudinal targeted next-generation sequencing in a patient with acute myeloid leukaemia.

Velu PD et al.

British Journal of Haematology, 2019

Molecular profiling of metastatic colorectal tumors using next-generation sequencing: a single-institution experience.

Gong J et al.

Oncotarget, 2017

Clinicopathological characteristics and prognostic impact of colorectal cancers with NRAS mutations.

Ogura T et al.

Oncology Reports, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."