Varaico: Literature-Extracted Genetic Variants

Gene:NRAS
Variant:p.Q61E
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NRAS

NM_002524.5:p.Q61E

Associated Papers

Thymus-like phenotype in benign lymphoepithelial neoplasms of salivary glands: clinicopathological and molecular characterization and reappraisal of relationship to non-sebaceous lymphadenoma.

Agaimy A et al.

Virchows Archiv : an International Journal of Pathology, 2025

Liquid Biopsy as a Means of Assessing Prognosis and Identifying Novel Risk Factors in Multiple Myeloma.

Soloveva M et al.

International Journal of Molecular Sciences, 2025

40943426 (PubMed )
Supplement: ijms-26-08505-s001.zip › Supplementary_Initial_data.xls › 24_patients_with_plasm.

Clonal haematopoiesis associates with distinct cytometric changes of red blood cells and platelets.

Salzbrunn JB et al.

British Journal of Haematology, 2025

40754673 (PubMed )
Supplement: BJH-207-1085-s002.xlsx › MCV_cohort

PIK3CB Inhibitor GSK2636771 in Cancers With PTEN Mutation/Deletion or Loss of PTEN Protein Expression: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols N and P.

Janku F et al.

Jco Precision Oncology, 2025

40865033 (PubMed )
Supplement: protocol1_PO-25-00265.pdf

Clonal Hematopoiesis of Indeterminate Potential Is Associated With Incident Abdominal Aortic Aneurysm.

Tan Y et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2025

40336477 (PubMed )
Supplement: atvb-2024-322630-s01.pdf

Comparative analysis of RNA expression in a single institution cohort of pediatric cancer patients.

Vasquez YA et al.

Npj Precision Oncology, 2025

40119139 (PubMed )
Supplement: 41698_2025_852_MOESM11_ESM.xlsx › Supplementary_Data_9

Multicenter In-House Evaluation of an Amplicon-Based Next-Generation Sequencing Panel for Comprehensive Molecular Profiling.

Jantus-Lewintre E et al.

Molecular Diagnosis & Therapy, 2025

39798063 (PubMed )
Supplement: 40291_2024_766_MOESM2_ESM.xlsx › S1c-Control_D_2_HD827

Limited Efficacy of Anti-EGFR Monoclonal Antibodies in Colorectal Cancer Patients with Rare RAS Variants: Analysis of the C-CAT Database.

Suzuki S et al.

Current Issues in Molecular Biology, 2024

Exploring the Relationship Between KRAS, NRAS, and BRAF Mutations and Clinical Characteristics in Iranian Colorectal Cancer Patients.

Mosaferi Z et al.

Journal of Gastrointestinal Cancer, 2024

Clinical features associated with NeoRAS wild-type metastatic colorectal cancer A SCRUM-Japan GOZILA substudy.

Osumi H et al.

Nature Communications, 2024

Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma.

Sementsov M et al.

Embo Molecular Medicine, 2024

Identification and analysis of oncogenic non-synonymous single nucleotide polymorphisms in the human NRAS gene: An exclusive in silico study.

Mozibullah M et al.

Journal, Genetic Engineering & Biotechnology, 2024

38797553 (PubMed )
Supplement: mmc1.xlsx › Table_1

Temporal dynamics of RAS mutations in circulating tumor DNA in metastatic colorectal cancer: clinical significance of mutation loss during treatment.

Iguchi K et al.

Journal of Cancer Research and Clinical Oncology, 2024

A multi-institutional observational study evaluating the incidence and the clinicopathological characteristics of NeoRAS wild-type metastatic colorectal cancer.

Osumi H et al.

Translational Oncology, 2023

KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics.

Voutsadakis IA

Critical Reviews in Oncology/hematology, 2023

Clinical Validation of Plasma-Based Genotyping for RAS and BRAF V600E Mutation in Metastatic Colorectal Cancer: SCRUM-Japan GOZILA Substudy.

Aoki Y et al.

Jco Precision Oncology, 2023

KRAS mutation as a predictor of insufficient trastuzumab efficacy and poor prognosis in HER2-positive advanced gastric cancer.

Shimozaki K et al.

Journal of Cancer Research and Clinical Oncology, 2023

Case Report: Longitudinal monitoring of clonal evolution by circulating tumor DNA for resistance to anti-EGFR antibody in a case of metastatic colorectal cancer.

Sagawa T et al.

Frontiers in Oncology, 2023

Molecular and clinical profile of patients referred as Noonan or Noonan-like syndrome in Greece: a cohort of 86 patients.

Papadopoulos G et al.

European Journal of Pediatrics, 2022

Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers.

Kobayashi Y et al.

Nature, 2022

C677T and A1298C MTHFR gene polymorphisms and response to fluoropyrimidine-based chemotherapy in Mestizo patients with metastatic colorectal cancer.

Ramos-Esquivel A et al.

Pharmacogenetics and Genomics, 2021

Concordance of acquired mutations between metastatic lesions and liquid biopsy in metastatic colorectal cancer.

Taniguchi F et al.

Future Science Oa, 2021

Infrequent RAS mutation is not associated with specific histological phenotype in gliomas.

Makino Y et al.

Bmc Cancer, 2021

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

Loree JM et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2021

Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutations.

Tripathi S et al.

Bioinformatics (oxford, England), 2021

33226070 (PubMed )
Supplement: btaa972_supplementary_data.zip › TableS2_RAS_Variants_CompScores.xlsx › Sheet_1

Sequence Neighborhoods Enable Reliable Prediction of Pathogenic Mutations in Cancer Genomes.

Banerjee S et al.

Cancers, 2021

34068918 (PubMed )
Supplement: cancers-13-02366-s001.zip › Supplementary_Tables_1202501.xlsx › Table_S7

Atypical BRAF and NRAS Mutations in Mucosal Melanoma.

Dumaz N et al.

Cancers, 2019

RAS Mutation in Mucinous Carcinoma of the Ovary

Panyavaranant P et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2019

Clinical relevance of circulating tumor DNA assessed through deep sequencing in patients with metastatic colorectal cancer.

Osumi H et al.

Cancer Medicine, 2019

A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Muñoz-Maldonado C et al.

Frontiers in Oncology, 2019

Clinical Validation of Newly Developed Multiplex Kit Using Luminex xMAP Technology for Detecting Simultaneous RAS and BRAF Mutations in Colorectal Cancer: Results of the RASKET-B Study.

Taniguchi H et al.

Neoplasia (new York, N.y.), 2018

Integrative omics analyses broaden treatment targets in human cancer.

Sengupta S et al.

Genome Medicine, 2018

30053901 (PubMed )
Supplement: 13073_2018_564_MOESM2_ESM.xlsx › 3

Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, Third Edition.

Yamazaki K et al.

Cancer Science, 2018

29873882 (PubMed )
Supplement: CAS-109-2074-s001.pdf

Clinical performance evaluation of the Idylla NRAS-BRAF mutation test on retrospectively collected formalin-fixed paraffin-embedded colorectal cancer tissue.

Johnston L et al.

Journal of Clinical Pathology, 2018

Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids.

Pan Y et al.

Scientific Reports, 2017

Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells.

Posch C et al.

The Journal of Investigative Dermatology, 2016

Integrated digital error suppression for improved detection of circulating tumor DNA.

Newman AM et al.

Nature Biotechnology, 2016

27018799 (PubMed )
Supplement: NIHMS764326-supplement-6.xlsx › SuppTable4_hotspot_variants

Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer.

Xu N et al.

Oncotarget, 2016

26646697 (PubMed )
Supplement: oncotarget-07-3884-s001.pdf

The diagnostic application of RNA sequencing in patients with thyroid cancer: an analysis of 851 variants and 133 fusions in 524 genes.

Pagan M et al.

Bmc Bioinformatics, 2016

26818556 (PubMed )
Supplement: 12859_2015_849_MOESM3_ESM.pdf

Using a constraint-based regression method for relative quantification of somatic mutations in pyrosequencing signals: a case for NRAS analysis.

Ambroise J et al.

Algorithms for Molecular Biology : Amb, 2016

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.

Feng Y et al.

Cancer Research, 2015

The Genetic Evolution of Melanoma from Precursor Lesions.

Shain AH et al.

The New England Journal of Medicine, 2015

26559571 (PubMed )
Supplement: nejmoa1502583_appendix_4.xlsx › Sheet1

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma.

Hutchinson KE et al.

Oncotarget, 2015

26084293 (PubMed )
Supplement: oncotarget-06-22348-s002.xlsx › Vertical

Real-Life Distribution of KRAS and NRAS Mutations in Metastatic Colorectal Carcinoma from French Routine Genotyping.

Piton N et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2015

Prognostic and predictive values of oncogenic BRAF, NRAS, c-KIT and MITF in cutaneous and mucous melanoma.

Pracht M et al.

Journal of the European Academy of Dermatology and Venereology : Jeadv, 2015

Clinical Validation of a Multiplex Kit for RAS Mutations in Colorectal Cancer: Results of the RASKET (RAS KEy Testing) Prospective, Multicenter Study.

Yoshino T et al.

Ebiomedicine, 2015

Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas.

Tone AA et al.

Bmc Cancer, 2014

25523272 (PubMed )
Supplement: 12885_2014_5198_MOESM14_ESM.xlsx › Sheet1__2_
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."