Varaico: Literature-Extracted Genetic Variants

Gene:NTRK1
Variant:p.D668N
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NTRK1

NM_002529.4:p.D668N

Associated Papers

Predictors of immunotherapy benefit in Merkel cell carcinoma.

Kacew AJ et al.

Oncotarget, 2020

Phase and context shape the function of composite oncogenic mutations.

Gorelick AN et al.

Nature, 2020

32461694 (PubMed )
Supplement: NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx › Table_S2._Composite_mutations

Activating mutations cluster in the "molecular brake" regions of protein kinases and do not associate with conserved or catalytic residues.

Molina-Vila MA et al.

Human Mutation, 2014

Gain of function mutations of RTK conserved residues display differential effects on NTRK1 kinase activity.

Miranda C et al.

Oncogene, 2002

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."