Associated Papers
Pharmacogenetic Analysis of TPMT and NUDT15 in a European Pediatric Cohort with IBD and Autoimmune Diseases: Frequency Data and Clinical Relevance.
Pau A et al.
Genes, 2025
NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy.
Lubis IS et al.
Medical Sciences (basel, Switzerland), 2025
Validation of diagnostic screening test for pharmacogenomic targets for thiopurine drugs in indian pediatric acute lymphoblastic leukemia patients.
Joseph GT et al.
Frontiers in Pharmacology, 2025
Phenotype driven molecular genetic test recommendation for diagnosing pediatric rare disorders.
Chen F et al.
Npj Digital Medicine, 2024
Universal Targeted Haplotyping by Droplet Digital PCR Sequencing and Its Applications in Noninvasive Prenatal Testing and Pharmacogenetics Analysis.
Gai W et al.
Clinical Chemistry, 2024
Influence of TPMT and NUDT15 Genetic Polymorphisms on Mercaptopurine Pharmacokinetics in Healthy Volunteers.
Kong Q et al.
Genetic Testing and Molecular Biomarkers, 2024
Concordance of phenotypic characteristics among patients with familial Crohn's disease in China.
Deng XX et al.
Journal of Digestive Diseases, 2024
Association of NUDT15 gene polymorphism with adverse reaction, treatment efficacy, and dose of 6-mercaptopurine in patients with acute lymphoblastic leukemia: a systematic review and meta-analysis.
Du S et al.
Haematologica, 2024
A New Cloud-Native Tool for Pharmacogenetic Analysis.
Yuan DY et al.
Genes, 2024
Genetic profiling of NUDT15 in the Slovenian population.
Šmid A et al.
Pharmacogenomics, 2024
Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Yu N et al.
Journal of Crohn's & Colitis, 2023
A Simple, Rapid, and Cost-Effective PCR Procedure for Detection of NUDT15 Gene Variants in Vietnamese Patients with Acute Lymphoblastic Leukemia.
Tram DB et al.
Journal of Laboratory Physicians, 2023
Comparative assessment of anti-cancer drugs against NUDT15 variants to prevent leucopenia side effect in leukemia patients.
V J et al.
Journal, Genetic Engineering & Biotechnology, 2023
Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease.
Suzuki S et al.
Bmc Gastroenterology, 2023
Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation.
He X et al.
Veterinary Sciences, 2023
The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia.
Nguyen ML et al.
Hgg Advances, 2023
Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.
Isono T et al.
Biological & Pharmaceutical Bulletin, 2023
Long-read HiFi sequencing of NUDT15: Phased full-gene haplotyping and pharmacogenomic allele discovery.
Scott ER et al.
Human Mutation, 2022
The effects of NUDT15 and TPMT variants on mercaptopurine treatment in Vietnamese pediatric acute lymphoblastic leukemia patients.
Nghia H et al.
Pediatric Hematology and Oncology, 2022
A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population.
Poon KS et al.
Bmc Research Notes, 2022
ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia.
Fan POL et al.
Pediatric Hematology and Oncology, 2022
Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.
Lanillos J et al.
Npj Genomic Medicine, 2022
Pharmacogenetics of Drugs Used in the Treatment of Cancers.
Franczyk B et al.
Genes, 2022
A rare case of Azathioprine-induced leukopenia in an European woman.
Séverine W et al.
Acta Clinica Belgica, 2022
Identification of pharmacogenetic variants from large scale next generation sequencing data in the Saudi population.
Goljan E et al.
Plos One, 2022
NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities.
Zhang F et al.
Frontiers in Pediatrics, 2022
Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse Population.
Khoo XH et al.
Frontiers in Medicine, 2022
Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising "MINT" sequencing strategy and therapeutic "DNA-TG" monitoring.
Guo HL et al.
Frontiers in Pharmacology, 2022
NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.
Somazu S et al.
Journal of Cellular and Molecular Medicine, 2021
Practical Considerations for Using RNA Sequencing in Management of B-Lymphoblastic Leukemia: Malaysia-Singapore Acute Lymphoblastic Leukemia 2020 Implementation Strategy.
Ni Chin WH et al.
The Journal of Molecular Diagnostics : Jmd, 2021
Genetic landscape of 125 pharmacogenes in Chinese from the Chinese Millionome Database.
Qi G et al.
Scientific Reports, 2021
Importance of NUDT15 Polymorphisms in Thiopurine Treatments.
Tanaka Y et al.
Journal of Personalized Medicine, 2021
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir.
Nishii R et al.
Nature Communications, 2021
An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia.
Tanaka Y et al.
Haematologica, 2021
NUDT15 polymorphism in healthy children with Bai nationality in Yunnan of China.
Pu G et al.
Pediatrics International : Official Journal of the Japan Pediatric Society, 2021
Genome wide association studies for treatment-related adverse effects of pediatric acute lymphoblastic leukemia.
Franca R et al.
Wires Mechanisms of Disease, 2021
Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis.
Jena A et al.
Expert Review of Clinical Pharmacology, 2021
The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia.
Lee JM et al.
Children (basel, Switzerland), 2021
Genetic Polymorphisms of Drug-Metabolizing Enzymes Involved in 6-Mercaptopurine-Induced Myelosuppression in Thai Pediatric Acute Lymphoblastic Leukemia Patients.
Khaeso K et al.
Journal of Pediatric Genetics, 2021
Pharmacogenetic determinants of thiopurines in an Indian cohort.
Naushad SM et al.
Pharmacological Reports : Pr, 2021
Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants.
Wang DS et al.
Pediatric Research, 2021
Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection.
Scott SA et al.
Clinical and Translational Science, 2021
Promising genes and variants to reduce chemotherapy adverse effects in acute lymphoblastic leukemia.
Bárcenas-López DA et al.
Translational Oncology, 2021
Meta-Analysis of NUDT15 Genetic Polymorphism on Thiopurine-Induced Myelosuppression in Asian Populations.
Khaeso K et al.
Frontiers in Pharmacology, 2021
Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients.
Yu CH et al.
Scientific Reports, 2020
Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis.
Tomiyoshi K et al.
Internal Medicine (tokyo, Japan), 2020
NUDT15 gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease.
Matsuoka K
Intestinal Research, 2020