Associated Papers
Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6-Mercaptopurine Treatment.
Khaeso K et al.
Clinical and Translational Science, 2026
Pharmacogenetic Analysis of TPMT and NUDT15 in a European Pediatric Cohort with IBD and Autoimmune Diseases: Frequency Data and Clinical Relevance.
Pau A et al.
Genes, 2025
Concordance of phenotypic characteristics among patients with familial Crohn's disease in China.
Deng XX et al.
Journal of Digestive Diseases, 2024
Association of NUDT15 gene polymorphism with adverse reaction, treatment efficacy, and dose of 6-mercaptopurine in patients with acute lymphoblastic leukemia: a systematic review and meta-analysis.
Du S et al.
Haematologica, 2024
Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Yu N et al.
Journal of Crohn's & Colitis, 2023
Characteristics and prognosis of rrDLBCL with TP53 mutations and a high-risk subgroup represented by the co-mutations of DDX3X-TP53.
Gao F et al.
Cancer Medicine, 2023
Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation.
He X et al.
Veterinary Sciences, 2023
The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia.
Nguyen ML et al.
Hgg Advances, 2023
ABCC4, ITPA, NUDT15, TPMT and their interaction as genetic predictors of 6-mercaptopurine intolerance in chinese patients with acute lymphoblastic leukemia.
Fan POL et al.
Pediatric Hematology and Oncology, 2022
A rare case of Azathioprine-induced leukopenia in an European woman.
Séverine W et al.
Acta Clinica Belgica, 2022
NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities.
Zhang F et al.
Frontiers in Pediatrics, 2022
An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia.
Tanaka Y et al.
Haematologica, 2021
NUDT15 polymorphism in healthy children with Bai nationality in Yunnan of China.
Pu G et al.
Pediatrics International : Official Journal of the Japan Pediatric Society, 2021
Genome wide association studies for treatment-related adverse effects of pediatric acute lymphoblastic leukemia.
Franca R et al.
Wires Mechanisms of Disease, 2021
Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis.
Jena A et al.
Expert Review of Clinical Pharmacology, 2021
Genetic Polymorphisms of Drug-Metabolizing Enzymes Involved in 6-Mercaptopurine-Induced Myelosuppression in Thai Pediatric Acute Lymphoblastic Leukemia Patients.
Khaeso K et al.
Journal of Pediatric Genetics, 2021
Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants.
Wang DS et al.
Pediatric Research, 2021
Meta-Analysis of NUDT15 Genetic Polymorphism on Thiopurine-Induced Myelosuppression in Asian Populations.
Khaeso K et al.
Frontiers in Pharmacology, 2021
Genetic Landscape of Relapsed and Refractory Diffuse Large B-Cell Lymphoma: A Systemic Review and Association Analysis With Next-Generation Sequencing.
Gao F et al.
Frontiers in Genetics, 2021
Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients.
Yu CH et al.
Scientific Reports, 2020
Rapid whole-exome sequencing facilitates precision medicine in paediatric rare disease patients and reduces healthcare costs.
Chung CCY et al.
The Lancet Regional Health. Western Pacific, 2020
NUDT15 gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease.
Matsuoka K
Intestinal Research, 2020
NUDT15 genetic variants are related to thiopurine-induced neutropenia in Thai children with acute lymphoblastic leukemia.
Puangpetch A et al.
Pharmacogenomics, 2020
[Significance of NUDT15 gene in individualized treatment with 6-mercaptopurine in children with acute lymphoblastic leukemia].
He J et al.
Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 2019
Association between the c.415C > T, c.52G > A, and 36_37insGGAGTC polymorphisms of NUDT 15 and thiopurine-induced leukopenia, thiopurine intolerance, and severe hair loss: an updated meta-analysis.
Wang R et al.
Drug Design, Development and Therapy, 2019
Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms.
Tsujimoto S et al.
Leukemia, 2018
NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia.
Yi ES et al.
Cancer Research and Treatment, 2018
Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity.
Shah SAV et al.
Drug Metabolism and Personalized Therapy, 2018
Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines.
Kojima Y et al.
World Journal of Gastroenterology, 2018
Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients.
Sutiman N et al.
Pharmacogenomics, 2018
Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.
Chao K et al.
Inflammatory Bowel Diseases, 2017
NUDT15 genotype distributions in the Korean population.
Kim HT et al.
Pharmacogenetics and Genomics, 2017
Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.
Shah SA et al.
Journal of Gastroenterology and Hepatology, 2017
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.
Moriyama T et al.
Nature Genetics, 2016
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Rehling D et al.
The Journal of Biological Chemistry, 0
Time to incorporate preemptive NUDT15 testing before starting thiopurines in inflammatory bowel disease in Asia and beyond: a review.
Desai D et al.
Expert Review of Clinical Pharmacology, 0