Associated Papers
Pharmacogenetic Analysis of TPMT and NUDT15 in a European Pediatric Cohort with IBD and Autoimmune Diseases: Frequency Data and Clinical Relevance.
Pau A et al.
Genes, 2025
Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia.
Newman H et al.
Hemasphere, 2025
Japanese medicinal drug labeling for use in the clinical setting as informed by pharmacogenomic data on cytochrome P450 enzymes obtained from in silico studies.
Tanaka Y et al.
Drug Metabolism and Pharmacokinetics, 2025
NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy.
Lubis IS et al.
Medical Sciences (basel, Switzerland), 2025
Clinical Actionability of the NUDT15 *4 (p.R139H) Allele and Its Association With Hispanic Ethnicity.
Maillard M et al.
Clinical Pharmacology and Therapeutics, 2025
The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.
Wang LY et al.
Innovation (cambridge (mass.)), 2025
Validation of diagnostic screening test for pharmacogenomic targets for thiopurine drugs in indian pediatric acute lymphoblastic leukemia patients.
Joseph GT et al.
Frontiers in Pharmacology, 2025
Phenotype driven molecular genetic test recommendation for diagnosing pediatric rare disorders.
Chen F et al.
Npj Digital Medicine, 2024
Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study.
Makuuchi M et al.
Journal of Gastroenterology, 2024
The frequency of NUDT15 rs116855232 and its impact on mercaptopurine-induced toxicity in Syrian children with acute lymphoblastic leukemia.
Muhammad M et al.
Frontiers in Oncology, 2024
Genetic profiling of NUDT15 in the Slovenian population.
Šmid A et al.
Pharmacogenomics, 2024
Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Yu N et al.
Journal of Crohn's & Colitis, 2023
Comparative assessment of anti-cancer drugs against NUDT15 variants to prevent leucopenia side effect in leukemia patients.
V J et al.
Journal, Genetic Engineering & Biotechnology, 2023
The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia.
Nguyen ML et al.
Hgg Advances, 2023
Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia.
Isono T et al.
Biological & Pharmaceutical Bulletin, 2023
Development of Novel Mass Spectrum-Based Assay for Simultaneous Detection of 36 Variants in the 14 Pharmacogenetic Genes for the Japanese Population.
Yamamoto N et al.
Biological & Pharmaceutical Bulletin, 2023
Molecular dynamics simulations reveal the impact of NUDT15 R139C and R139H variants in structural conformation and dynamics.
Gómez-Rubio E et al.
Journal of Biomolecular Structure & Dynamics, 2023
Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review.
Gu J et al.
Frontiers in Pharmacology, 2023
The effects of NUDT15 and TPMT variants on mercaptopurine treatment in Vietnamese pediatric acute lymphoblastic leukemia patients.
Nghia H et al.
Pediatric Hematology and Oncology, 2022
A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population.
Poon KS et al.
Bmc Research Notes, 2022
Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.
Lanillos J et al.
Npj Genomic Medicine, 2022
Pharmacogenetics of Drugs Used in the Treatment of Cancers.
Franczyk B et al.
Genes, 2022
NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities.
Zhang F et al.
Frontiers in Pediatrics, 2022
NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.
Somazu S et al.
Journal of Cellular and Molecular Medicine, 2021
Importance of NUDT15 Polymorphisms in Thiopurine Treatments.
Tanaka Y et al.
Journal of Personalized Medicine, 2021
Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance.
Cagiada M et al.
Molecular Biology and Evolution, 2021
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir.
Nishii R et al.
Nature Communications, 2021
NUDT15 polymorphism in healthy children with Bai nationality in Yunnan of China.
Pu G et al.
Pediatrics International : Official Journal of the Japan Pediatric Society, 2021
Genome wide association studies for treatment-related adverse effects of pediatric acute lymphoblastic leukemia.
Franca R et al.
Wires Mechanisms of Disease, 2021
The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia.
Lee JM et al.
Children (basel, Switzerland), 2021
Genetic Polymorphisms of Drug-Metabolizing Enzymes Involved in 6-Mercaptopurine-Induced Myelosuppression in Thai Pediatric Acute Lymphoblastic Leukemia Patients.
Khaeso K et al.
Journal of Pediatric Genetics, 2021
Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants.
Wang DS et al.
Pediatric Research, 2021
Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection.
Scott SA et al.
Clinical and Translational Science, 2021
Promising genes and variants to reduce chemotherapy adverse effects in acute lymphoblastic leukemia.
Bárcenas-López DA et al.
Translational Oncology, 2021
Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis.
Tomiyoshi K et al.
Internal Medicine (tokyo, Japan), 2020
NUDT15 gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease.
Matsuoka K
Intestinal Research, 2020
Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease.
Su SS et al.
Chinese Medical Journal, 2020
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity.
Suiter CC et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15R138C knock-in mice.
Tatsumi G et al.
Leukemia, 2020
High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codon 18 rendering the NUDT15 diplotype.
Kakuta Y et al.
Journal of Gastroenterology, 2020
Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil.
Rodrigues JCG et al.
Plos One, 2020
Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia.
Choi R et al.
British Journal of Clinical Pharmacology, 2019
Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian Patients.
Park SC et al.
Cells, 2019
Thiopurine intolerance-causing mutations in NUDT15 induce temperature-dependent destabilization of the catalytic site.
Man P et al.
Biochimica Et Biophysica Acta. Proteins and Proteomics, 2019
The Nudix Hydrolase 15 (NUDT15) Gene Variants among Jordanian Arab Population
Jarrar YB et al.
Asian Pacific Journal of Cancer Prevention : Apjcp, 2019