Varaico: Literature-Extracted Genetic Variants

Gene:OGG1
Variant:p.R229Q
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OGG1

NM_002542.6:p.R229Q

Associated Papers

Integrative Computational Analysis of Common EXO5 Haplotypes: Impact on Protein Dynamics, Genome Stability, and Cancer Progression.

Mazza F et al.

Journal of Chemical Information and Modeling, 2025

40115981 (PubMed )
Supplement: ci5c00067_si_002.xlsx › scored_ALL_haplotypes_1MAF_cano

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Valerie NCK et al.

Nature Communications, 2024

DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms.

Rahimian E et al.

Dna Repair, 2020

The correlation of combined OGG1, CYP1A1 and GSTP1 gene variants and risk of lung cancer of male Iraqi waterpipe tobacco smokers.

Kudhair BK et al.

Molecular Biology Reports, 2020

Structural and Functional Analysis of human lung cancer risk associated hOGG1 variant Ser326Cys in DNA repair gene by molecular dynamics simulation.

Abduljaleel Z

Non-coding Rna Research, 2019

OGG1 rs1052133 Polymorphism and Genetic Susceptibility to Chronic Myelogenous Leukaemia

Hassan FM

Asian Pacific Journal of Cancer Prevention : Apjcp, 2019

Association between hOGG1 Polymorphisms and Pancreatic Cancer Susceptibility: A Meta-analysis.

Xu X et al.

Journal of the College of Physicians and Surgeons--pakistan : Jcpsp, 2018

Studies of Correlations Between Single Nucleotide Polymorphisms of DNA Repair Genes and Endometrial Cancer in Polish Women.

Smolarz B et al.

Anticancer Research, 2018

A systematic review and meta-analysis of the association between OGG1 Ser326Cys polymorphism and cancers.

Zhou PT et al.

Medical Oncology (northwood, London, England), 2015

Association between single-nucleotide polymorphisms of OGG1 gene and pancreatic cancer risk in Chinese Han population.

Chen H et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2014

Alzheimer's disease-associated polymorphisms in human OGG1 alter catalytic activity and sensitize cells to DNA damage.

Jacob KD et al.

Free Radical Biology & Medicine, 2013

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair.

German P et al.

Dna Repair, 2013

Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk.

Zhong DY et al.

Genetics and Molecular Research : Gmr, 2012

Lack of association between hOGG1 Ser326Cys polymorphism and the risk of bladder cancer: a meta-analysis.

Li D et al.

Urologia Internationalis, 2012

Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).

Noren Hooten N et al.

The Journal of Biological Chemistry, 2011

Variation in base excision repair capacity.

Wilson DM et al.

Mutation Research, 2011

Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.

Jeannot E et al.

Diabetes, 2010

20393147 (PubMed )
Supplement: supp_db09-1819_onlineappendix.pdf

Synergistic effects of polymorphisms in DNA repair genes and endogenous estrogen exposure on female breast cancer risk.

Ming-Shiean H et al.

Annals of Surgical Oncology, 2010

Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase.

Sidorenko VS et al.

The Febs Journal, 2009

Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.

Ryu GM et al.

Nucleic Acids Research, 2009

19139070 (PubMed )
Supplement: gkn1008_nar-01723-s-2008-File009.xls › TypeIII

The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis.

Li H et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2008

Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.

McWilliams RR et al.

Cancer Research, 2008

Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosis.

Habib SL et al.

Cancer Biology & Therapy, 2008

A novel R229Q OGG1 polymorphism results in a thermolabile enzyme that sensitizes KG-1 leukemia cells to DNA damaging agents.

Hill JW et al.

Cancer Detection and Prevention, 2007

Targeting of mutant hogg1 in mammalian mitochondria and nucleus: effect on cellular survival upon oxidative stress.

Chatterjee A et al.

Bmc Cancer, 2006

Radiation-induced gene expression profile of human cells deficient in 8-hydroxy-2'-deoxyguanine glycosylase.

Chaudhry MA

International Journal of Cancer, 2006

Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk.

Le Marchand L et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2002

Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects.

Tan YC et al.

Cancer Detection and Prevention, 2001

Molecular dynamics approach to identification of new OGG1 cancer-associated somatic variants with impaired activity.

Popov AV et al.

The Journal of Biological Chemistry, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."