Varaico: Literature-Extracted Genetic Variants

Gene:OPN1MW
Variant:p.P301S
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OPN1MW

NM_000513.2:p.P301S

Associated Papers

Understanding Tau pathology: Insights from animal models.

Zhang H et al.

Zoological Research, 2025

Distinct neuronal vulnerability and metabolic dysfunctions are characteristic features of fast-progressing Alzheimer's patients with Lewy bodies.

Rahman MW et al.

The Journal of Biological Chemistry, 2025

Sensitive detection and propagation of brain-derived tau assemblies in HEK293-based wild-type tau seeding assays.

Huang M et al.

The Journal of Biological Chemistry, 2025

Functional classification of tauopathy strains reveals the role of protofilament core residues.

Vaquer-Alicea J et al.

Science Advances, 2025

39841851 (PubMed )
Supplement: sciadv.adp5978_data_s1.zip › adp5978_data_s1.xlsx › Fig.4-5___Sup.Fig.5-6__LM_Scans

p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.

Taylor LW et al.

Acta Neuropathologica, 2024

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Panzi C et al.

Toxicon : Official Journal of the International Society on Toxinology, 2023

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.

Lester E et al.

Neuron, 2021

Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice.

Zareba-Paslawska J et al.

Frontiers in Neurology, 2020

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.

Yamazaki Y et al.

Nature Reviews. Neurology, 2019

Ordered Assembly of Tau Protein and Neurodegeneration.

Goedert M et al.

Advances in Experimental Medicine and Biology, 2019

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.

Malmanche N et al.

Scientific Reports, 2017

In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy.

Crescenzi R et al.

Neuroimage, 2014

Phenotypic variation of autosomal-dominant corticobasal degeneration.

Jung HH et al.

European Neurology, 2012

Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy.

Kertesz A et al.

Journal of the Neurological Sciences, 2010

Tau protein and neurodegeneration.

Goedert M

Seminars in Cell & Developmental Biology, 2004

Frontotemporal dementia and tauopathy.

Yoshiyama Y et al.

Current Neurology and Neuroscience Reports, 2001

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