Associated Papers
Pharmacogenomic profile of actionable molecular variants related to drugs commonly used in anesthesia: WES analysis reveals new mutations.
Parada-Márquez JF et al.
Frontiers in Pharmacology, 2023
Whole exome/genome sequencing in cyclic vomiting syndrome reveals multiple candidate genes, suggesting a model of elevated intracellular cations and mitochondrial dysfunction.
Bar O et al.
Frontiers in Neurology, 2023
Implication of OPRM1 A118G Polymorphism in Opioids Addicts in Pakistan: In vitro and In silico Analysis.
Ahmed M et al.
Journal of Molecular Neuroscience : Mn, 2018
Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses.
Kringel D et al.
The Pharmacogenomics Journal, 2017
Convergent Balancing Selection on the Mu-Opioid Receptor in Primates.
Sweeney CG et al.
Molecular Biology and Evolution, 2017
Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.
Cereda M et al.
Nature Communications, 2016
Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms.
López Soto EJ et al.
Genetics and Molecular Biology, 2015
Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1).
Knapman A et al.
British Journal of Pharmacology, 2015
Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine.
Clarke TK et al.
Neuroscience Letters, 2013
Elucidation of mu-Opioid Gene Structure: How Genetics Can Help Predict Responses to Opioids.
Diatchenko L et al.
European Journal of Pain Supplements, 2011
The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.
Fortin JP et al.
Molecular Pharmacology, 2010
OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.
Mague SD et al.
Drug and Alcohol Dependence, 2010
Functional characterization of human variants of the mu-opioid receptor gene.
Ravindranathan A et al.
Proceedings of the National Academy of Sciences of the United States of America, 2009
Analysis of SNP profiles in patients with major depressive disorder.
Kõks S et al.
The International Journal of Neuropsychopharmacology, 2006
Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.
Zhang H et al.
Human Molecular Genetics, 2006
[Are polymorphisms in the mu-opioid receptor important for opioid therapy?].
Lötsch J et al.
Schmerz (berlin, Germany), 2005
COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms.
Goldman D et al.
Journal of Studies on Alcohol. Supplement, 2005
Gene polymorphisms of the mu opioid receptor in methamphetamine abusers.
Ide S et al.
Annals of the New York Academy of Sciences, 2004
Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor.
Beyer A et al.
Journal of Neurochemistry, 2004
Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?
Lötsch J et al.
Anesthesiology, 2002
A polymorphism (A118G) in the mu-opioid receptor gene affects the response to morphine-6-glucuronide in humans.
Höllt V
Pharmacogenetics, 2002
Bioinformatic analysis of the human mu opioid receptor (OPRM1) splice and polymorphic variants.
Xin L et al.
Aaps Pharmsci, 2002
Detection of single nucleotide polymorphisms of the human mu opioid receptor gene by hybridization or single nucleotide extension on custom oligonucleotide gelpad microchips: potential in studies of addiction.
LaForge KS et al.
American Journal of Medical Genetics, 2000
Association analysis of polymorphisms in the μ opioid gene and heroin abuse in Chinese subjects.
Li T et al.
Addiction Biology, 2000
Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects.
Gelernter J et al.
Molecular Psychiatry, 1999
Relevance of frequent mu-opioid receptor polymorphisms for opioid activity in healthy volunteers.
Lötsch J et al.
The Pharmacogenomics Journal, 0
Mu opioid receptor gene variants: lack of association with alcohol dependence.
Bergen AW et al.
Molecular Psychiatry, 0