Varaico: Literature-Extracted Genetic Variants

Gene:OPRM1
Variant:p.R181C
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OPRM1

NM_000914.5:p.R181C

Associated Papers

Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort.

Åkerlund M et al.

Pain, 2025

Molecular basis for the selective G protein signaling of somatostatin receptors.

Chen S et al.

Nature Chemical Biology, 2023

Novel variants of engineered water soluble mu opioid receptors with extensive mutations and removal of cysteines.

Xi J et al.

Proteins, 2021

Convergent Balancing Selection on the Mu-Opioid Receptor in Primates.

Sweeney CG et al.

Molecular Biology and Evolution, 2017

The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses.

Skorpen F et al.

Acta Anaesthesiologica Scandinavica, 2016

A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro.

Knapman A et al.

British Journal of Pharmacology, 2015

Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1).

Knapman A et al.

British Journal of Pharmacology, 2015

Buprenorphine signalling is compromised at the N40D polymorphism of the human μ opioid receptor in vitro.

Knapman A et al.

British Journal of Pharmacology, 2014

Functional characterization of human variants of the mu-opioid receptor gene.

Ravindranathan A et al.

Proceedings of the National Academy of Sciences of the United States of America, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."