Varaico: Literature-Extracted Genetic Variants

Gene:OPRM1
Variant:p.N190K
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OPRM1

NM_000914.5:p.N190K

Associated Papers

Convergent Balancing Selection on the Mu-Opioid Receptor in Primates.

Sweeney CG et al.

Molecular Biology and Evolution, 2017

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.

Shi X et al.

Plos One, 2016

Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1).

Knapman A et al.

British Journal of Pharmacology, 2015

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.

Cooke AE et al.

British Journal of Pharmacology, 2015

A heroin addiction severity-associated intronic single nucleotide polymorphism modulates alternative pre-mRNA splicing of the μ opioid receptor gene OPRM1 via hnRNPH interactions.

Xu J et al.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2014

Elucidation of mu-Opioid Gene Structure: How Genetics Can Help Predict Responses to Opioids.

Diatchenko L et al.

European Journal of Pain Supplements, 2011

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.

Fortin JP et al.

Molecular Pharmacology, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."