Varaico: Literature-Extracted Genetic Variants

Gene:OPRM1
Variant:p.R265H
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OPRM1

NM_000914.5:p.R265H

Associated Papers

The Influence of OPRM1 A118G Polymorphism on the Dosage of Morphine in Patients with Advanced Liver Cancer.

Cheng H et al.

Journal of the College of Physicians and Surgeons--pakistan : Jcpsp, 2021

Overview of Genetic Analysis of Human Opioid Receptors.

Spampinato SM

Methods in Molecular Biology (clifton, N.j.), 2021

Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1).

Knapman A et al.

British Journal of Pharmacology, 2015

Mu opioid receptor gene: new point mutations in opioid addicts.

Dinarvand A et al.

Basic and Clinical Neuroscience, 2014

The mutational landscape of adenoid cystic carcinoma.

Ho AS et al.

Nature Genetics, 2013

23685749 (PubMed )
Supplement: NIHMS474972-supplement-1.pdf

Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirements in Chinese patients with cancer pain.

Gong XD et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2013

The genetics of the opioid system and specific drug addictions.

Levran O et al.

Human Genetics, 2012

Elucidation of mu-Opioid Gene Structure: How Genetics Can Help Predict Responses to Opioids.

Diatchenko L et al.

European Journal of Pain Supplements, 2011

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.

Fortin JP et al.

Molecular Pharmacology, 2010

OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.

Mague SD et al.

Drug and Alcohol Dependence, 2010

Novel linkage disequilibrium of single nucleotide polymorphisms in the transcriptional regulatory region of micro-opioid receptor gene in Japanese population.

Ono T et al.

Biological & Pharmaceutical Bulletin, 2009

Interindividual variability of methadone response: impact of genetic polymorphism.

Li Y et al.

Molecular Diagnosis & Therapy, 2008

[Are polymorphisms in the mu-opioid receptor important for opioid therapy?].

Lötsch J et al.

Schmerz (berlin, Germany), 2005

COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms.

Goldman D et al.

Journal of Studies on Alcohol. Supplement, 2005

Principles of pharmacogenetics--implications for the anaesthetist.

Iohom G et al.

British Journal of Anaesthesia, 2004

Association of mu-opioid receptor subunit gene and idiopathic generalized epilepsy.

Wilkie H et al.

Neurology, 2002

A polymorphism (A118G) in the mu-opioid receptor gene affects the response to morphine-6-glucuronide in humans.

Höllt V

Pharmacogenetics, 2002

Bioinformatic analysis of the human mu opioid receptor (OPRM1) splice and polymorphic variants.

Xin L et al.

Aaps Pharmsci, 2002

Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding.

Wang D et al.

The Journal of Biological Chemistry, 2001

A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling.

Befort K et al.

The Journal of Biological Chemistry, 2001

Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence.

Hoehe MR et al.

Human Molecular Genetics, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."