Associated Papers
OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathies.
Wang Q et al.
Communications Biology, 2025
Paucity of optineurin gene variants in Indian juvenile open-angle glaucoma patients.
Yadav M et al.
Indian Journal of Ophthalmology, 2025
Targeting mitophagy in neurodegenerative diseases.
Antico O et al.
Nature Reviews. Drug Discovery, 2025
Protein misfolding and mitochondrial dysfunction in glaucoma.
Venkatesan A et al.
Frontiers in Cell and Developmental Biology, 2025
[Optineurin and mitochondrial dysfunction in neurodegeneration].
D'Urso B et al.
Medecine Sciences : M/s, 2024
Molecular genetics of primary open-angle glaucoma.
Yadav M et al.
Indian Journal of Ophthalmology, 2023
Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma.
Duarte JN
Journal of Ophthalmology, 2021
Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.
Yamano K et al.
The Journal of Cell Biology, 2020
The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma.
Rozpędek-Kamińska W et al.
International Journal of Molecular Sciences, 2020
Glaucoma-Associated Mutations in the Optineurin Gene Have Limited Impact on Parkin-Dependent Mitophagy.
Chernyshova K et al.
Investigative Ophthalmology & Visual Science, 2019
Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.
Toth RP et al.
Frontiers in Immunology, 2018
Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.
Swarup G et al.
Frontiers in Immunology, 2018
Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer.
Weil R et al.
Frontiers in Immunology, 2018
Significance of optineurin mutations in glaucoma and other diseases.
Minegishi Y et al.
Progress in Retinal and Eye Research, 2016
Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins.
Li F et al.
Nature Communications, 2016
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nakazawa S et al.
Nature Communications, 2016
Defects in autophagy caused by glaucoma-associated mutations in optineurin.
Sirohi K et al.
Experimental Eye Research, 2016
Functional analysis of optineurin and some of its disease-associated mutants.
Bansal M et al.
Iubmb Life, 2015
Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.
Gao J et al.
Plos One, 2014
Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics.
Paulus JD et al.
Plos One, 2014
M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells.
Sirohi K et al.
Autophagy, 2013
Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina.
Meng Q et al.
Molecular Biology Reports, 2012
Cellular and molecular biology of optineurin.
Ying H et al.
International Review of Cell and Molecular Biology, 2012
Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis.
Del Bo R et al.
Journal of Neurology, Neurosurgery, and Psychiatry, 2011
Complex genetic mechanisms in glaucoma: an overview.
Rao KN et al.
Indian Journal of Ophthalmology, 2011
Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice.
Chi ZL et al.
Human Molecular Genetics, 2010
Optineurin and its mutants: molecules associated with some forms of glaucoma.
Chalasani ML et al.
Ophthalmic Research, 2009
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
Kumar A et al.
Molecular Vision, 2007
A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants.
Chalasani ML et al.
Investigative Ophthalmology & Visual Science, 2007
SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma.
Funayama T et al.
Investigative Ophthalmology & Visual Science, 2006
[Low penetrance of His26Asp mutation in the optineurin gene in a Japanese family with normal-tension glaucoma].
Yasuda N et al.
Nippon Ganka Gakkai Zasshi, 2006
Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.
Funayama T et al.
Investigative Ophthalmology & Visual Science, 2004
Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population.
Fuse N et al.
Journal of Glaucoma, 2004