Associated Papers
Familial Hyperkalemic Hypertension.
Cornelius RJ et al.
Comprehensive Physiology, 2024
WNK4 kinase: from structure to physiology.
Murillo-de-Ozores AR et al.
American Journal of Physiology. Renal Physiology, 2021
Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters.
Murillo-de-Ozores AR et al.
Frontiers in Physiology, 2020
SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3.
Borrás J et al.
Nephron, 2015
SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
Elvira B et al.
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2015
WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
Xie J et al.
The Journal of Biological Chemistry, 2013
Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.
Nishida H et al.
Hypertension (dallas, Tex. : 1979), 2012
SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.
Thastrup JO et al.
The Biochemical Journal, 2012
Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.
Chiga M et al.
Journal of Cell Science, 2011
Role of the WNK-activated SPAK kinase in regulating blood pressure.
Rafiqi FH et al.
Embo Molecular Medicine, 2010
20091762 (PubMed )
Supplement: emmm0002-0063-SD1.pdf
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.
Zagórska A et al.
The Journal of Cell Biology, 2007
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
Vitari AC et al.
The Biochemical Journal, 2006
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
Vitari AC et al.
The Biochemical Journal, 2005
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