Associated Papers
PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome.
Sheedy CJ et al.
The Journal of Biological Chemistry, 2025
Programmable protein stabilization with language model-derived peptide guides.
Hong L et al.
Nature Communications, 2025
PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome.
Sheedy CJ et al.
Biorxiv : the Preprint Server for Biology, 2024
OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination.
Peng L et al.
Cellular Oncology (dordrecht, Netherlands), 2024
Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via β-catenin/necroptosis signal pathway.
Liao Y et al.
International Journal of Biological Sciences, 2024
OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6.
Zhao Y et al.
Clinical and Translational Medicine, 2023
Structural Basis of Ubiquitin Recognition by a Bacterial Ovarian Tumor Deubiquitinase LotA.
Takekawa N et al.
Journal of Bacteriology, 2022
The ubiquitin-like modifier FAT10 stimulates the activity of deubiquitylating enzyme OTUB1.
Bialas J et al.
The Journal of Biological Chemistry, 2019
OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination.
Pasupala N et al.
The Journal of Biological Chemistry, 2018
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
Baietti MF et al.
Embo Molecular Medicine, 2016
Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice.
Kato K et al.
Molecular Cell, 2014
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Wiener R et al.
Nature Structural & Molecular Biology, 2013
OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.
Herhaus L et al.
Nature Communications, 2013
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
Juang YC et al.
Molecular Cell, 2012
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.
Sun XX et al.
The Embo Journal, 2012
Structural basis and specificity of human otubain 1-mediated deubiquitination.
Edelmann MJ et al.
The Biochemical Journal, 2009