Associated Papers
DUBA sustains the stability of NOD2 and RIPK2 to enhance innate immune responses.
Zhou B et al.
Cell Death and Differentiation, 2025
p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer.
Zhang J et al.
Clinical and Translational Medicine, 2025
The deubiquitinase OTUD5 stabilizes SLC7A11 to promote progression and reduce paclitaxel sensitivity in triple-negative breast cancer.
Liu X et al.
Cancer Letters, 2024
OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1S824.
Lam SY et al.
Nature Communications, 2024
OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation.
Liu Y et al.
Cell Death and Differentiation, 2024
Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury.
Chu LK et al.
Nature Communications, 2023
Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.
Hou T et al.
Cell Death & Disease, 2022
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.
Liu Q et al.
Elife, 2022
Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.
Cho JH et al.
Cell Death and Differentiation, 2021
Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation.
Beck DB et al.
Science Advances, 2021
OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.
Li F et al.
Nature Communications, 2020
Analysis of deubiquitinase OTUD5 as a biomarker and therapeutic target for cervical cancer by bioinformatic analysis.
Bai M et al.
Peerj, 2020
The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining.
Li F et al.
Cellular and Molecular Life Sciences : Cmls, 2019
The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.
de Vivo A et al.
Nucleic Acids Research, 2019
A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway.
Guven-Maiorov E et al.
Biophysical Journal, 2015
Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress.
Park SY et al.
Cancer Letters, 2015
Phosphorylation-dependent activity of the deubiquitinase DUBA.
Huang OW et al.
Nature Structural & Molecular Biology, 2012
DUBA: a deubiquitinase that regulates type I interferon production.
Kayagaki N et al.
Science (new York, N.y.), 2007