Varaico: Literature-Extracted Genetic Variants

Gene:OTUD7B
Variant:p.C194S
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OTUD7B

NM_020205.4:p.C194S

Associated Papers

The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination.

Wang L et al.

Plos Biology, 2025

OTUD7B is a new deubiquitinase targeting p53.

Ding C et al.

Theranostics, 2025

Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.

Wu X et al.

Genes & Development, 2019

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.

Cui CP et al.

Nature Communications, 2018

Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates.

Bonacci T et al.

The Embo Journal, 2018

Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains.

Kniss A et al.

Structure (london, England : 1993), 2018

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.

Mevissen TET et al.

Nature, 2016

Cezanne regulates E2F1-dependent HIF2α expression.

Moniz S et al.

Journal of Cell Science, 2015

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

Bremm A et al.

Embo Reports, 2014

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.

Licchesi JD et al.

Nature Structural & Molecular Biology, 2011

22157957 (PubMed )
Supplement: NIHMS36793-supplement-Supplementary_Material.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."