Associated Papers
M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress.
Elbæk CR et al.
Cell Death and Differentiation, 2026
Linear ubiquitination triggers Amph-mediated T-tubule biogenesis.
Kawaguchi K et al.
Science Advances, 2026
Monogenic disorders of the TNF signalling pathway.
Lalaoui N et al.
Nature Reviews. Rheumatology, 2026
Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity.
Zhang Y et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2025
Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival.
Zein L et al.
Autophagy, 2025
OTULIN-related conditions: Report of a new case and review of the literature using GenIA.
Caballero-Oteyza A et al.
Clinical Immunology (orlando, Fla.), 2024
Dominant negative OTULIN-related autoinflammatory syndrome.
Davidson S et al.
The Journal of Experimental Medicine, 2024
A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome.
Takeda Y et al.
The Journal of Experimental Medicine, 2024
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Fu Y et al.
Nature Communications, 2024
OTULIN-related conditions: Report of a new case and review of the literature using GenIA.
Caballero-Oteyza A et al.
Research Square, 2024
OTULIN deficiency: focus on innate immune system impairment.
Dou B et al.
Frontiers in Immunology, 2024
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections.
Chi X et al.
Science China. Life Sciences, 2023
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development.
Li M et al.
Cell Death and Differentiation, 2022
Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA.
Luo J et al.
The Journal of Biological Chemistry, 2022
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Guo Y et al.
Oncogene, 2022
Substrate-assisted activation and selectivity of the bacterial RavD effector deubiquitinylase.
Schulze-Niemand E et al.
Proteins, 2022
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
Zinngrebe J et al.
Embo Molecular Medicine, 2022
Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production.
Tao P et al.
Science Advances, 2021
Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Abdul Rehman SA et al.
Molecular Cell, 2021
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity.
Hoste E et al.
Nature Communications, 2021
OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.
Fu Y et al.
Molecular Cell, 2021
Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond.
Weinelt N et al.
Cell Death and Differentiation, 2021
The Met1-linked ubiquitin machinery in inflammation and infection.
Fiil BK et al.
Cell Death and Differentiation, 2021
Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
Fennell LM et al.
The Embo Journal, 2020
Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders.
Oikawa D et al.
International Journal of Molecular Sciences, 2020
Regulation of the endosomal SNX27-retromer by OTULIN.
Stangl A et al.
Nature Communications, 2019
Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation.
Gabrielsen M et al.
Structure (london, England : 1993), 2019
A protein quality control pathway regulated by linear ubiquitination.
van Well EM et al.
The Embo Journal, 2019
OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death.
Damgaard RB et al.
Embo Molecular Medicine, 2019
Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.
Morrow ME et al.
Embo Reports, 2018
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Damgaard RB et al.
Cell, 2016
Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.
Caulfield TR et al.
Plos Computational Biology, 2014
Molecular basis and regulation of OTULIN-LUBAC interaction.
Elliott PR et al.
Molecular Cell, 2014
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
Fiil BK et al.
Molecular Cell, 2013
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Rivkin E et al.
Nature, 2013
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.
Keusekotten K et al.
Cell, 2013