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P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity.
Gasparri F et al.
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35285517 (PubMed )
Supplement: BPH-179-3859-s004.xlsx › Genetic_Variations
High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism.
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The Journal of Biological Chemistry, 2012
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