Associated Papers
P2RX7, an adaptive immune response gene, is associated with Parkinson's disease risk and age at onset.
Shani S et al.
Journal of Parkinson's Disease, 2024
P2X7 Variants in Pathophysiology.
Pegoraro A et al.
International Journal of Molecular Sciences, 2024
Human P2X7 receptor variants Gly150Arg and Arg276His polymorphisms have differential effects on risk association and cellular functions in pancreatic cancer.
Magni L et al.
Cancer Cell International, 2024
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO).
Charras A et al.
Journal of Autoimmunity, 2024
Characterization of Common Genetic Variants in P2RX7 and Their Contribution to Chronic Pain Conditions.
Zorina-Lichtenwalter K et al.
The Journal of Pain, 2024
Origin, distribution, and function of three frequent coding polymorphisms in the gene for the human P2X7 ion channel.
Schäfer W et al.
Frontiers in Pharmacology, 2022
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP.
Jiang LH et al.
Purinergic Signalling, 2021
Association between P2X7 Polymorphisms and Post-Transplant Outcomes in Allogeneic Haematopoietic Stem Cell Transplantation.
Koldej RM et al.
International Journal of Molecular Sciences, 2020
The presence of the 1068 G>A variant of P2X7 receptors is associated to an increase in IL-1Ra levels, insulin secretion and pancreatic β-cell function but not with glycemic control in type 2 diabetes patients.
Uresti-Rivera EE et al.
Gene, 2018
Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis.
Sadovnick AD et al.
Human Mutation, 2017
A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.
Gu BJ et al.
Human Molecular Genetics, 2015
Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl.
Ide S et al.
Molecular Pain, 2014
R270C polymorphism leads to loss of function of the canine P2X7 receptor.
Spildrejorde M et al.
Physiological Genomics, 2014
Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjögren's syndrome.
Lester S et al.
Arthritis Research & Therapy, 2013
A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration.
Gu BJ et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2013
Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms.
Jiang LH et al.
Frontiers in Pharmacology, 2013
Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures.
Jørgensen NR et al.
European Journal of Human Genetics : Ejhg, 2012
Role of purinergic receptor polymorphisms in human bone.
Wesselius A et al.
Frontiers in Bioscience (landmark Edition), 2011
Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7.
Adriouch S et al.
Purinergic Signalling, 2009
P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.
Lucae S et al.
Human Molecular Genetics, 2006