Associated Papers
Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation.
Leandro J et al.
Biochimica Et Biophysica Acta, 2011
Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis.
Stokka AJ et al.
The Journal of Biological Chemistry, 2004
Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237.
Thórólfsson M et al.
Biochemistry, 2003
A comparison of kinetic and regulatory properties of the tetrameric and dimeric forms of wild-type and Thr427-->Pro mutant human phenylalanine hydroxylase: contribution of the flexible hinge region Asp425-Gln429 to the tetramerization and cooperative substrate binding.
Bjørgo E et al.
European Journal of Biochemistry, 2001
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