Associated Papers
PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain.
Wang Y et al.
Cellular and Molecular Life Sciences : Cmls, 2025
Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions.
Wang Y et al.
Biorxiv : the Preprint Server for Biology, 2024
FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes.
Saito K et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2024
MICAL1 activation by PAK1 mediates actin filament disassembly.
McGarry DJ et al.
Cell Reports, 2022
Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction.
Misra S et al.
Frontiers in Cell and Developmental Biology, 2021
Insights into evolutionary interaction patterns of the 'Phosphorylation Activation Segment' in kinase.
Ahiri A et al.
Bioinformation, 2019
Activating Mutations in PAK1, Encoding p21-Activated Kinase 1, Cause a Neurodevelopmental Disorder.
Harms FL et al.
American Journal of Human Genetics, 2018
Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
Pellegrini E et al.
Plos One, 2017
PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).
Barrows D et al.
The Journal of Biological Chemistry, 2016
Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases.
Xu Q et al.
Science Signaling, 2015
Myosin 3A kinase activity is regulated by phosphorylation of the kinase domain activation loop.
Quintero OA et al.
The Journal of Biological Chemistry, 2013
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors.
Habif G et al.
Journal of Proteomics, 2013
The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.
Combeau G et al.
The Journal of Biological Chemistry, 2012
Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.
Nie J et al.
The Journal of Biological Chemistry, 2012
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling.
Shrestha Y et al.
Oncogene, 2012
The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes.
Singhal R et al.
Oncotarget, 2012
Structural insights into the autoactivation mechanism of p21-activated protein kinase.
Wang J et al.
Structure (london, England : 1993), 2011
Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.
Lee SH et al.
Cell Death & Disease, 2011
p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
Thévenot E et al.
The Journal of Biological Chemistry, 2011
Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.
Venkatareddy M et al.
Plos One, 2011
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.
Polzien L et al.
The Journal of Biological Chemistry, 2009
Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells.
Hage B et al.
Cell Communication and Signaling : Ccs, 2009
PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.
Gringel A et al.
Journal of Cellular Physiology, 2006
Essential requirement for Rho family GTPase signaling in Pax3 induced mesenchymal-epithelial transition.
Wiggan O et al.
Cellular Signalling, 2006
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.
Pirruccello M et al.
Journal of Molecular Biology, 2006
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.
Zhao L et al.
Nature Neuroscience, 2006
PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis.
Even-Faitelson L et al.
Cellular Signalling, 2005
The active conformation of the PAK1 kinase domain.
Lei M et al.
Structure (london, England : 1993), 2005
Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion.
De Corte V et al.
Journal of Cell Science, 2004
Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization.
Papakonstanti EA et al.
Molecular Biology of the Cell, 2002
Cell cycle-regulated phosphorylation of p21-activated kinase 1.
Thiel DA et al.
Current Biology : Cb, 2002
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.
Parrini MC et al.
Molecular Cell, 2002
p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain.
Hullinger TG et al.
The Journal of Biological Chemistry, 2001
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Lei M et al.
Cell, 2000
In vivo activity of wild-type and mutant PAKs.
King CC et al.
Methods in Enzymology, 2000
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.
Johnson DI
Microbiology and Molecular Biology Reviews : Mmbr, 1999