Associated Papers
Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes.
Nishikawa M et al.
Cells, 2022
De novo variants in PAK1 lead to intellectual disability with macrocephaly and seizures.
Horn S et al.
Brain : a Journal of Neurology, 2019
Activating Mutations in PAK1, Encoding p21-Activated Kinase 1, Cause a Neurodevelopmental Disorder.
Harms FL et al.
American Journal of Human Genetics, 2018
Kinase-independent role for CRAF-driving tumour radioresistance via CHK2.
Advani SJ et al.
Nature Communications, 2015
B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.
Tran NH et al.
The Journal of Biological Chemistry, 2005
p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.
Vadlamudi RK et al.
Embo Reports, 2004
Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.
Tran NH et al.
The Journal of Biological Chemistry, 2003
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.
Chong C et al.
The Journal of Biological Chemistry, 2001
Regulation of the enzymatic and motor activities of myosin I.
Barylko B et al.
Biochimica Et Biophysica Acta, 2000
Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation.
Frost JA et al.
The Journal of Biological Chemistry, 1998
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