Associated Papers
PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain.
Wang Y et al.
Cellular and Molecular Life Sciences : Cmls, 2025
Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions.
Wang Y et al.
Biorxiv : the Preprint Server for Biology, 2024
MICAL1 activation by PAK1 mediates actin filament disassembly.
McGarry DJ et al.
Cell Reports, 2022
Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction.
Misra S et al.
Frontiers in Cell and Developmental Biology, 2021
The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences.
Sun X et al.
The Journal of Biological Chemistry, 2019
Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.
Nie J et al.
The Journal of Biological Chemistry, 2012
Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.
Lee SH et al.
Cell Death & Disease, 2011
A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families.
Zhu G et al.
The Journal of Biological Chemistry, 2005
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.
Parrini MC et al.
Molecular Cell, 2002
p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain.
Hullinger TG et al.
The Journal of Biological Chemistry, 2001
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