Varaico: Literature-Extracted Genetic Variants

Gene:PAK4
Variant:p.K350M
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PAK4

NM_005884.5:p.K350M

Associated Papers

Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation.

Su VL et al.

The Journal of Biological Chemistry, 2020

Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover.

Li Z et al.

Molecular Biology of the Cell, 2010

N-terminal interaction domain implicates PAK4 in translational regulation and reveals novel cellular localization signals.

Baldassa S et al.

Journal of Cellular Physiology, 2010

p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration.

Li Z et al.

The Journal of Biological Chemistry, 2010

PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.

Gringel A et al.

Journal of Cellular Physiology, 2006

Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines.

Callow MG et al.

The Journal of Biological Chemistry, 2002

Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.

Dan C et al.

The Journal of Biological Chemistry, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."