Varaico: Literature-Extracted Genetic Variants

Gene:PALB2
Variant:p.S145C
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PALB2

NM_024675.4:p.S145C

Associated Papers

Site-saturation functional screens identify PALB2 missense variants associated with increased breast cancer risk.

Boonen RACM et al.

Nature Communications, 2026

41554690 (PubMed )
Supplement: 41467_2025_67252_MOESM6_ESM.xlsx › SpliceAI_middle_region

The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction.

Kyriukha Y et al.

Iscience, 2024

The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction.

Kyriukha Y et al.

Biorxiv : the Preprint Server for Biology, 2024

The PALB2 DNA-binding domain is an intrinsically disordered recombinase.

Kyriukha Y et al.

Research Square, 2023

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."