Associated Papers
The reaction mechanism for glycolysis side product degradation by Parkinson's disease-linked DJ-1.
Watanabe A et al.
The Journal of Cell Biology, 2025
DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride.
Akhmadi A et al.
Nature Communications, 2024
Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite.
Heremans IP et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
Comparative analysis of web-based programs for single amino acid substitutions in proteins.
Choudhury A et al.
Plos One, 2022
Extracellular DJ-1 induces sterile inflammation in the ischemic brain.
Nakamura K et al.
Plos Biology, 2021
DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondria.
Ozawa K et al.
Scientific Reports, 2020
DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN.
Niki T et al.
Brain Research, 2020
Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
Dolgacheva LP et al.
Journal of Bioenergetics and Biomembranes, 2019
A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1.
Mussakhmetov A et al.
Biochemical and Biophysical Research Communications, 2018
Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
Biosa A et al.
Neurobiology of Disease, 2017
Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.
Matsuda N et al.
Scientific Reports, 2017
Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.
Richarme G et al.
Science (new York, N.y.), 2017
DJ-1 as a Therapeutic Target Against Cancer.
Cao J et al.
Advances in Experimental Medicine and Biology, 2017
Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease.
Johnson WM et al.
Biochemistry, 2016
Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild-type DJ-1.
Kojima W et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2016
DJ-1 activates SIRT1 through its direct binding to SIRT1.
Takahashi-Niki K et al.
Biochemical and Biophysical Research Communications, 2016
Epidermal Growth Factor-dependent Activation of the Extracellular Signal-regulated Kinase Pathway by DJ-1 Protein through Its Direct Binding to c-Raf Protein.
Takahashi-Niki K et al.
The Journal of Biological Chemistry, 2015
Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
Choi MS et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2014
Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers.
Prahlad J et al.
Journal of Neurochemistry, 2014
Thermodynamic and structural characterization of the specific binding of Zn(II) to human protein DJ-1.
Tashiro S et al.
Biochemistry, 2014
Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner.
Kato I et al.
Molecular and Cellular Biology, 2013
Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants.
Maita C et al.
Plos One, 2013
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.
Ishikawa S et al.
Biochemical and Biophysical Research Communications, 2012
YajL, prokaryotic homolog of parkinsonism-associated protein DJ-1, functions as a covalent chaperone for thiol proteome.
Le HT et al.
The Journal of Biological Chemistry, 2012
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
Yamaguchi S et al.
Plos One, 2012
[Function of DJ-1 in mitochondria].
Takahashi-Niki K et al.
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan, 2012
Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN.
Kim YC et al.
International Journal of Oncology, 2009
Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1.
Ishikawa S et al.
The Journal of Biological Chemistry, 2009
Protection against oxidative stress-induced neurodegeneration by a modulator for DJ-1, the wild-type of familial Parkinson's disease-linked PARK7.
Yanagida T et al.
Journal of Pharmacological Sciences, 2009
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection.
Junn E et al.
Journal of Neuroscience Research, 2009
Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Witt AC et al.
Biochemistry, 2008
DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy.
Koide-Yoshida S et al.
International Journal of Molecular Medicine, 2007
Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1.
Ito G et al.
Biochemical and Biophysical Research Communications, 2006
Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.
Shinbo Y et al.
Cell Death and Differentiation, 2006
Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients.
Takahashi-Niki K et al.
Biochemical and Biophysical Research Communications, 2004
DJ-1 has a role in antioxidative stress to prevent cell death.
Taira T et al.
Embo Reports, 2004