Associated Papers
PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex.
Robu M et al.
Nucleic Acids Research, 2025
Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage.
Zhu F et al.
Nature Chemical Biology, 2025
DNMT1 is required for efficient DSB repair and maintenance of replication fork stability, and its loss reverses resistance to PARP inhibitors in cancer cells.
Wu W et al.
Oncogene, 2025
The PARP1-EXD2 axis orchestrates R-loop resolution to safeguard genome stability.
Li Z et al.
Nature Chemical Biology, 2025
XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites.
Lin X et al.
Nucleic Acids Research, 2025
Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.
Lin X et al.
Molecular Cell, 2024
Regulation of PARP1/2 and the tankyrases: emerging parallels.
Jessop M et al.
The Biochemical Journal, 2024
Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.
Lin X et al.
Biorxiv : the Preprint Server for Biology, 2024
PAR recognition by PARP1 regulates DNA-dependent activities and independently stimulates catalytic activity of PARP1.
Deeksha W et al.
The Febs Journal, 2023
Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.
Shao Z et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage.
Fu H et al.
Nature Cell Biology, 2022
Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.
Shao Z et al.
Nucleic Acids Research, 2020
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.
Caron MC et al.
Nature Communications, 2019
PARP2 mediates branched poly ADP-ribosylation in response to DNA damage.
Chen Q et al.
Nature Communications, 2018
Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.
Steffen JD et al.
Nucleic Acids Research, 2016
Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.
Steffen JD et al.
Cancer Research, 2014
Dual roles of PARP-1 promote cancer growth and progression.
Schiewer MJ et al.
Cancer Discovery, 2012
ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity.
Wu X et al.
Plos One, 2012
The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.
Langelier MF et al.
The Journal of Biological Chemistry, 2010