Associated Papers
PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed.
Elsborg JD et al.
Molecular Cell, 2025
Poly-(ADP-ribose) serves as a scaffold for the methyltransferase METTL3/14 complex in the DNA damage response.
Gonzalez-Leal C et al.
Nucleic Acids Research, 2025
SMAD4 Limits PARP1 dependent DNA Repair to Render Pancreatic Cancer Cells Sensitive to Radiotherapy.
Wang Y et al.
Cell Death & Disease, 2024
PARP1 UFMylation ensures the stability of stalled replication forks.
Gong Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development.
Kamaletdinova T et al.
Cells, 2023
HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage.
Smith R et al.
Nature Structural & Molecular Biology, 2023
PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response.
Reber JM et al.
Cell Biology and Toxicology, 2023
LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin.
Bao K et al.
Genome Biology, 2022
PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells.
Sadhukhan R et al.
Life Sciences, 2021
Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair.
Pfeiffer A et al.
Journal of Cell Science, 2021
Direct measurement of protein-protein interactions by FLIM-FRET at UV laser-induced DNA damage sites in living cells.
Kaufmann T et al.
Nucleic Acids Research, 2020
The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
Juhász S et al.
Science Advances, 2020
Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.
Shao Z et al.
Nucleic Acids Research, 2020
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.
Gatti M et al.
Cell Reports, 2020
Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter.
Tian YN et al.
Cell Death & Disease, 2020
Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.
Bolderson E et al.
Nature Communications, 2019
MORC2 regulates DNA damage response through a PARP1-dependent pathway.
Zhang L et al.
Nucleic Acids Research, 2019
PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner.
Veith S et al.
Scientific Reports, 2019
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.
Caron MC et al.
Nature Communications, 2019
Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells.
Sullivan-Reed K et al.
Cell Reports, 2018
Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.
Krastev DB et al.
Nature Communications, 2018
SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients.
Mei Z et al.
Bmc Cancer, 2018
A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF.
Choi J et al.
Nature Genetics, 2017
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
Li J et al.
Science (new York, N.y.), 2017
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.
Rank L et al.
Nucleic Acids Research, 2016
PARP1 regulates the protein stability and proapoptotic function of HIPK2.
Choi JR et al.
Cell Death & Disease, 2016
Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.
Eustermann S et al.
Molecular Cell, 2015
Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer.
Brodie SA et al.
Oncotarget, 2015
The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.
Breslin C et al.
Nucleic Acids Research, 2015
Dynamic regulation of Rad51 by E2F1 and p53 in prostate cancer cells upon drug-induced DNA damage under hypoxia.
Wu M et al.
Molecular Pharmacology, 2014
PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation.
O'Donnell A et al.
Embo Reports, 2013