Associated Papers
Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells.
Pires MJ et al.
The Journal of Biological Chemistry, 2025
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.
Valerie NCK et al.
Nature Communications, 2024
Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.
Rouleau-Turcotte É et al.
Molecular Cell, 2022
PARP1: Structural insights and pharmacological targets for inhibition.
Spiegel JO et al.
Dna Repair, 2021
PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.
van Beek L et al.
International Journal of Molecular Sciences, 2021
SMURF2-mediated ubiquitin signaling plays an essential role in the regulation of PARP1 PARylating activity, molecular interactions, and functions in mammalian cells.
Ilić N et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2021
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Ogden TEH et al.
Nucleic Acids Research, 2021
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.
Rank L et al.
Nucleic Acids Research, 2016
Conformational activation of poly(ADP-ribose) polymerase-1 upon DNA binding revealed by small-angle X-ray scattering.
Mansoorabadi SO et al.
Biochemistry, 2014
Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.
Langelier MF et al.
Science (new York, N.y.), 2012
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