Varaico: Literature-Extracted Genetic Variants

Gene:PARP2
Variant:p.E545A
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PARP2

NM_001042618.2:p.E545A

Associated Papers

XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites.

Lin X et al.

Nucleic Acids Research, 2025

Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.

Lin X et al.

Molecular Cell, 2024

XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites.

Lin X et al.

Biorxiv : the Preprint Server for Biology, 2024

Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.

Lin X et al.

Biorxiv : the Preprint Server for Biology, 2024

PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.

Lin X et al.

Nucleic Acids Research, 2022

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage.

Chen Q et al.

Nature Communications, 2018

PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection.

Fouquin A et al.

Nucleic Acids Research, 2017

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.

Riccio AA et al.

Nucleic Acids Research, 2016

PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.

Langelier MF et al.

Nucleic Acids Research, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."