Associated Papers
Advancing inducible gene-inactivation systems to explore synthetic lethality.
Sánta ÁT et al.
Nar Cancer, 2026
Human DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation.
Moreno NC et al.
Nucleic Acids Research, 2026
Microhomology-mediated end joining acts directly on replication forks to repair single-ended double strand breaks.
Li S et al.
Biorxiv : the Preprint Server for Biology, 2026
Lnk deficiency enhances translesion synthesis to alleviate replication stress and promote hematopoietic stem cell fitness.
Singh B et al.
The Journal of Clinical Investigation, 2026
PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast.
Markowska K et al.
Nature Communications, 2025
The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses.
Cui S et al.
Biorxiv : the Preprint Server for Biology, 2025
Ubiquitin protease Ubp1 cooperates with Ubp10 and Ubp12 to revert lysine-164 PCNA ubiquitylation at replication forks.
Zamarreño J et al.
Nucleic Acids Research, 2025
Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination.
Rogers CB et al.
Biomolecules, 2025
Hypoxia-dependent recruitment of error-prone DNA polymerases to genome replication.
Yehuda R et al.
Oncogene, 2025
Molecular dependencies and genomic consequences of a global DNA damage tolerance defect.
de Groot D et al.
Genome Biology, 2024
PCNA and Rnh1 independently participate in the protection of mitochondrial genome against UV-induced mutagenesis in yeast cells.
Latoszek M et al.
Scientific Reports, 2024
PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling.
Yang Y et al.
Nucleic Acids Research, 2024
The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination-Deficient Tumors.
Cadzow L et al.
Cancer Research, 2024
DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation.
Moreno NC et al.
Biorxiv : the Preprint Server for Biology, 2024
The fork remodeler helicase-like transcription factor in cancer development: all at once.
Waheed Y et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2024
Cell type specific suppression of hyper-recombination by human RAD18 is linked to PCNA K164 ubiquitination.
Rogers CB et al.
Biorxiv : the Preprint Server for Biology, 2024
A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells.
Cybulla E et al.
Nucleic Acids Research, 2024
Effects of PCNA Stability on the Formation of Mutations.
Arbel-Groissman M et al.
International Journal of Molecular Sciences, 2024
Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair.
Shah R et al.
Pnas Nexus, 2024
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis.
Salas-Lloret D et al.
Nature Communications, 2024
Primordial germ cell DNA demethylation and development require DNA translesion synthesis.
Shah P et al.
Nature Communications, 2024
ATR limits Rad18-mediated PCNA monoubiquitination to preserve replication fork and telomerase-independent telomere stability.
Chen S et al.
The Embo Journal, 2024
FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination.
Leung W et al.
Cell Reports, 2023
Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase ζ and PRIMPOL.
Gyüre Z et al.
Cell Reports, 2023
Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase.
Fan L et al.
Mbio, 2023
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination.
Wang YC et al.
Cell Reports, 2023
Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy.
Anand J et al.
Nar Cancer, 2023
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination.
Wang YC et al.
Biorxiv : the Preprint Server for Biology, 2023
Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer.
Simoneau A et al.
Molecular Cancer Therapeutics, 2023
Mammalian life depends on two distinct pathways of DNA damage tolerance.
Buoninfante OA et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023
PCNA Ser46-Leu47 residues are crucial in preserving genomic integrity.
Kim S et al.
Plos One, 2023
Implications of Translesion DNA Synthesis Polymerases on Genomic Stability and Human Health.
Venkadakrishnan J et al.
Molecular and Cellular Biology, 2023
RAD18 opposes transcription-associated genome instability through FANCD2 recruitment.
Wells JP et al.
Plos Genetics, 2022
Mechanisms of PARP1 inhibitor resistance and their implications for cancer treatment.
Jackson LM et al.
Nar Cancer, 2022
Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling.
Thakar T et al.
Nature Communications, 2022
Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer.
Luong TT et al.
Plos Genetics, 2022
S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit.
Choudhary K et al.
Mbio, 2022
Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass.
Wegmann S et al.
Molecular Cell, 2022
Characterisation of the spectrum and genetic dependence of collateral mutations induced by translesion DNA synthesis.
Póti Á et al.
Plos Genetics, 2022