Varaico: Literature-Extracted Genetic Variants

Gene:PCNA
Variant:p.C81R
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PCNA

NM_182649.2:p.C81R

Associated Papers

A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder.

Magrino J et al.

The Journal of Biological Chemistry, 2023

Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling.

Thakar T et al.

Nature Communications, 2022

Ligation of newly replicated DNA controls the timing of DNA mismatch repair.

Reyes GX et al.

Current Biology : Cb, 2021

A new insight into protein-protein interactions and the effect of conformational alterations in PCNA.

Bhardwaj VK et al.

International Journal of Biological Macromolecules, 2020

Computational investigation on effect of mutations in PCNA resulting in structural perturbations and inhibition of mismatch repair pathway.

Bhardwaj V et al.

Journal of Biomolecular Structure & Dynamics, 2020

Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.

Paul Solomon Devakumar LJ et al.

Nucleic Acids Research, 2019

Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring.

Kondratick CM et al.

Plos One, 2018

DNA mismatch repair and its many roles in eukaryotic cells.

Liu D et al.

Mutation Research. Reviews in Mutation Research, 2017

The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.

Haye JE et al.

Plos Genetics, 2015

PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.

Goellner EM et al.

Molecular Cell, 2014

Distinct structural alterations in proliferating cell nuclear antigen block DNA mismatch repair.

Dieckman LM et al.

Biochemistry, 2013

Polymorphisms of survivin and its protein expression are associated with colorectal cancer susceptibility in Chinese population.

Li XB et al.

Dna and Cell Biology, 2013

Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.

Hombauer H et al.

Cell, 2011

Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair.

Lau PJ et al.

Molecular and Cellular Biology, 2002

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."