Associated Papers
CRISPR as a therapeutic tool for inherited retinal degenerations: Advances, challenges, and future directions.
Galdikaite-Braziene E et al.
Molecular Aspects of Medicine, 2026
In vivo prime editing rescues photoreceptor degeneration in nonsense mutant retinitis pigmentosa.
Fu Y et al.
Nature Communications, 2025
A Penetrable AAV2 Capsid Variant for Efficient Intravitreal Gene Delivery to the Retina.
He X et al.
Investigative Ophthalmology & Visual Science, 2025
Establishment and visual analysis of CBA/J-Pde6bY347Y/Y347X and C3H/HeJ-Pde6bY347Y/Y347X mice.
Shindo M et al.
Experimental Animals, 2024
Does Background Matter? A Comparative Characterization of Mouse Models of Autosomal Retinitis Pigmentosa rd1 and Pde6b-KO.
Chirinskaite AV et al.
International Journal of Molecular Sciences, 2023
Identification and Characterization of Retinitis Pigmentosa in a Novel Mouse Model Caused by PDE6B-T592I.
Xia CH et al.
Biomedicines, 2023
Whole-exome sequencing prioritizes candidate genes for hereditary cataract in the Emory mouse mutant.
Bennett TM et al.
G3 (bethesda, Md.), 2023
Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.
Mathur PD et al.
Scientific Reports, 2023
Toward the Treatment of Inherited Diseases of the Retina Using CRISPR-Based Gene Editing.
Hernández-Juárez J et al.
Frontiers in Medicine, 2021
Targeting the photoreceptor cilium for the treatment of retinal diseases.
Ran J et al.
Acta Pharmacologica Sinica, 2020
A novel mutation in PDE6B in Spanish Water Dogs with early-onset progressive retinal atrophy.
Winkler PA et al.
Veterinary Ophthalmology, 2020
Gene editing prospects for treating inherited retinal diseases.
Benati D et al.
Journal of Medical Genetics, 2020
In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway.
Cai Y et al.
Science Advances, 2019
Pde6brd1 mutation modifies cataractogenesis in Foxe3rct mice.
Wada K et al.
Biochemical and Biophysical Research Communications, 2018
Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice.
Bhatti F et al.
Plos One, 2018
A kind of rd1 mouse in C57BL/6J mice from crossing with a mutated Kunming mouse.
Yan W et al.
Gene, 2017
CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa.
Wu WH et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2016
The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.
Luhmann UF et al.
Human Molecular Genetics, 2015
Lrit3 deficient mouse (nob6): a novel model of complete congenital stationary night blindness (cCSNB).
Neuillé M et al.
Plos One, 2014
[Cause of retinitis pigmentosa and new therapeutics under development].
Sakamoto K et al.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica, 2011
Single-stranded oligonucleotide-mediated in vivo gene repair in the rd1 retina.
Andrieu-Soler C et al.
Molecular Vision, 2007
Heterozygous missense mutation in the rod cGMP phosphodiesterase beta-subunit gene in autosomal dominant stationary night blindness.
Gal A et al.
Nature Genetics, 1994
Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa.
McLaughlin ME et al.
Nature Genetics, 1993