Varaico: Literature-Extracted Genetic Variants

Gene:PDGFRA
Variant:p.G12D
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PDGFRA

NM_006206.6:p.G12D

Associated Papers

Genomic Profile of Non-Small Cell Lung Cancer in a Spanish Cohort: A 2-Year Descriptive Study Using Next-Generation Sequencing.

Carnero-Gregorio M et al.

Genes, 2026

Oral Melanocytic Neoplasms: A Narrative Review.

Maldonado-Mendoza J

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2025

Profiling of HER2, KRAS, and PIK3CA mutations in uterine cervical neuroendocrine carcinoma and implications for oncogenic driver targeting therapy.

Chao WR et al.

Cancer Genetics, 2025

Complement pathway activation mediates pancreatic cancer-induced muscle wasting and pathological remodeling.

D'Lugos AC et al.

The Journal of Clinical Investigation, 2025

Next-Generation Sequencing (NGS) in non-small cell lung carcinoma: A real-world experience in the public health system of Galicia (Northwest Spain).

Abdulkader-Nallib I et al.

Plos One, 2025

Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.

Jungholm O et al.

Scientific Reports, 2024

39179604 (PubMed )
Supplement: 41598_2024_70217_MOESM1_ESM.docx

Broad spectrum of regorafenib activity on mutant KIT and absence of clonal selection in gastrointestinal stromal tumor (GIST): correlative analysis from the GRID trial.

Jeffers M et al.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2022

35050442 (PubMed )
Supplement: 10120_2021_1274_MOESM1_ESM.docx

Papillary renal neoplasm with reverse polarity: A clinicopathological and molecular genetic characterization of 16 cases with expanding the morphologic spectrum and further support for a novel entity.

Shen M et al.

Frontiers in Oncology, 2022

Development and Validation of Targeted Gene Sequencing Panel Based Companion Diagnostic for Korean Patients with Solid Tumors.

Min BJ et al.

Cancers, 2021

Recurrent KRAS, KIT and SF3B1 mutations in melanoma of the female genital tract.

Cai YJ et al.

Bmc Cancer, 2021

Molecular epidemiology and diagnostics of KRAS mutations in human cancer.

Timar J et al.

Cancer Metastasis Reviews, 2020

Epidemiologic Features of NSCLC Gene Alterations in Hispanic Patients from Puerto Rico.

Zheng R et al.

Cancers, 2020

Combination of KRAS and SMAD4 mutations in formalin-fixed paraffin-embedded tissues as a biomarker for pancreatic cancer.

Yokose T et al.

Cancer Science, 2020

K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways.

Scheffler M et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2019

Mutational Aberrations Detected in Mucinous Epithelial Ovarian Cancer of Asian Women.

Chay WY et al.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, 2018

A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma.

Windon AL et al.

Journal of Gastrointestinal Oncology, 2018

Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer.

Adamo P et al.

Oncotarget, 2017

Mutational profiling of acral melanomas in Korean populations.

Shim JH et al.

Experimental Dermatology, 2017

Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease.

Garces S et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2017

Succinate dehydrogenase deficiency in a PDGFRA mutated GIST.

Belinsky MG et al.

Bmc Cancer, 2017

Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia.

Chakrabarty S et al.

British Journal of Cancer, 2017

RET Aberrations in Diverse Cancers: Next-Generation Sequencing of 4,871 Patients.

Kato S et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

27683183 (PubMed )
Supplement: 10780432ccr161679-sup-168576_1_supp_3636667_wcc1ns.docx

Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts.

Jones M et al.

Gastrointestinal Endoscopy, 2016

Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care.

Rennert H et al.

Npj Genomic Medicine, 2016

28781886 (PubMed )
Supplement: npjgenmed201619-s1.doc

Molecular profiles of high-grade and low-grade pseudomyxoma peritonei.

Noguchi R et al.

Cancer Medicine, 2015

Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.

Yu J et al.

Gut, 2015

24951259 (PubMed )
Supplement: gutjnl-2013-306620-s13.pdf

Rapid detection of genetic mutations in individual breast cancer patients by next-generation DNA sequencing.

Liu S et al.

Human Genomics, 2015

The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study.

Abdul-Jalil KI et al.

Annals of Surgical Oncology, 2014

Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin.

Zanaruddin SN et al.

Plos One, 2013

Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking BRAF inhibitors.

Anforth R et al.

Pigment Cell & Melanoma Research, 2012

KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors.

Miranda C et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2012

22282465 (PubMed )
Supplement: 10780432ccr112230-sup-t1_pdf_76k.pdf

KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.

Tie J et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21239505 (PubMed )
Supplement: 10780432ccr101720-sup-supplementary_tables_s1-s4.pdf

PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor.

Perrone F et al.

Neuro-oncology, 2009

Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene.

Walz C et al.

Genes, Chromosomes & Cancer, 2006

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."