Varaico: Literature-Extracted Genetic Variants

Gene:PDGFRA
Variant:p.D842E
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PDGFRA

NM_006206.6:p.D842E

Associated Papers

A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer.

Rangarajan A et al.

Frontiers in Oncology, 2025

Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.

Paolino J et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2023

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour.

Priya V et al.

Turk Patoloji Dergisi, 2020

Gastrointestinal Stromal Tumor: Genotype Frequency and Prognostic Relevance.

Kumari N et al.

Applied Immunohistochemistry & Molecular Morphology : Aimm, 2018

High-resolution melting analysis is a sensitive diagnostic tool to detect imatinib-resistant and imatinib-sensitive PDGFRA exon 18 mutations in gastrointestinal stromal tumors.

Künstlinger H et al.

Human Pathology, 2014

The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro.

von Bubnoff N et al.

Oncogene, 2011

A novel pathogenetic mutation in clonal eosinophilia.

Tefferi A

Current Hematology Reports, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."