Varaico: Literature-Extracted Genetic Variants

Gene:PDGFRB
Variant:p.Y1009F
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PDGFRB

NM_002609.4:p.Y1009F

Associated Papers

Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.

Reddi AL et al.

The Journal of Biological Chemistry, 2007

The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases.

Mitchell D et al.

The Journal of Biological Chemistry, 2007

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

Saxton TM et al.

The Embo Journal, 1997

Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.

Yokote K et al.

The Journal of Biological Chemistry, 1996

Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.

Mori S et al.

The Journal of Biological Chemistry, 1993

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."