Associated Papers
Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
Fan J et al.
Molecular Cell, 2016
SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.
Ozden O et al.
Free Radical Biology & Medicine, 2014
Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.
Fan J et al.
The Journal of Biological Chemistry, 2014
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
Fan J et al.
Molecular Cell, 2014
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