Varaico: Literature-Extracted Genetic Variants

Gene:PECAM1
Variant:p.Y663F
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PECAM1

NM_000442.5:p.Y663F

Associated Papers

CD31 regulates metabolic switch in Treg migration attenuates rheumatoid arthritis.

Liu M et al.

Clinical and Translational Medicine, 2025

L-selectin regulates human neutrophil transendothelial migration.

Rahman I et al.

Journal of Cell Science, 2021

PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells.

Wu N et al.

International Journal of Oncology, 2013

A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration.

Dasgupta B et al.

Journal of Immunology (baltimore, Md. : 1950), 2009

Role of immunoreceptor tyrosine-based inhibitory motifs of PECAM-1 in PECAM-1-dependent cell migration.

O'Brien CD et al.

American Journal of Physiology. Cell Physiology, 2004

Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif.

Gratzinger D et al.

Biochemical and Biophysical Research Communications, 2003

Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma1 with PECAM-1/CD31.

Pumphrey NJ et al.

Febs Letters, 1999

Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases.

Cao MY et al.

The Journal of Biological Chemistry, 1998

Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2.

Jackson DE et al.

The Journal of Biological Chemistry, 1997

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."