Associated Papers
Circadian clock gene variants in two Japanese families with familial advanced sleep phase.
Ukai M et al.
Sleep, 2025
Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1.
Harold RL et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein Kinase 1.
Harold RL et al.
Biorxiv : the Preprint Server for Biology, 2024
Variants in the circadian clock genes PER2 and PER3 associate with familial sleep phase disorders.
Plavc L et al.
Chronobiology International, 2024
Adaptive changes in BMAL2 with increased locomotion associated with the evolution of unihemispheric slow-wave sleep in mammals.
Yin D et al.
Sleep, 2024
Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability.
Mitchell CW et al.
The Journal of Biological Chemistry, 2022
The impact of Mendelian sleep and circadian genetic variants in a population setting.
Weedon MN et al.
Plos Genetics, 2022
Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction.
An Y et al.
Nature Communications, 2022
Toward a Molecular Approach to Chronotype Assessment.
Biscontin A et al.
Journal of Biological Rhythms, 2022
PhosVarDeep: deep-learning based prediction of phospho-variants using sequence information.
Liu X et al.
Peerj, 2022
Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia.
Masunaga Y et al.
Clinical Epigenetics, 2021
Sleep phenotype of individuals with autism spectrum disorder bearing mutations in the PER2 circadian rhythm gene.
Hoang N et al.
American Journal of Medical Genetics. Part A, 2021
The molecular genetics of human sleep.
Zhang L et al.
The European Journal of Neuroscience, 2020
The period circadian clock 2 gene responds to glucocorticoids and regulates osteogenic capacity.
Abe T et al.
Regenerative Therapy, 2019
Systematic analysis of the intersection of disease mutations with protein modifications.
Simpson CM et al.
Bmc Medical Genomics, 2019
TIMELESS mutation alters phase responsiveness and causes advanced sleep phase.
Kurien P et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Disruption of protein function by pathogenic mutations: common and uncommon mechanisms 1.
Taipale M
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 2019
Evaluation of the Association Between Genetic Variants in Circadian Rhythm Genes and Posttraumatic Stress Symptoms Identifies a Potential Functional Allele in the Transcription Factor TEF.
Linnstaedt SD et al.
Frontiers in Psychiatry, 2018
PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylation.
Patrick R et al.
Bioinformatics (oxford, England), 2017
An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression.
Akiyama T et al.
Plos One, 2017
Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.
Holehouse AS et al.
Plos One, 2015
A PER2-derived mechanism-based bisubstrate analog for casein kinase 1ε.
Zeringo NA et al.
Chemical Biology & Drug Design, 2014
PER1 phosphorylation specifies feeding rhythm in mice.
Liu Z et al.
Cell Reports, 2014
Association of the clock genes polymorphisms with colorectal cancer susceptibility.
Karantanos T et al.
Journal of Surgical Oncology, 2013
Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts.
Zienolddiny S et al.
Breast Cancer Research : Bcr, 2013
Diversity of human clock genotypes and consequences.
Zhang L et al.
Progress in Molecular Biology and Translational Science, 2013
The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis.
Gu X et al.
Cell Death and Differentiation, 2012
Casein kinase 1-dependent phosphorylation of familial advanced sleep phase syndrome-associated residues controls PERIOD 2 stability.
Shanware NP et al.
The Journal of Biological Chemistry, 2011
NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
Englund A et al.
Journal of Circadian Rhythms, 2009
Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.
Ryu GM et al.
Nucleic Acids Research, 2009
Casein kinase-1-epsilon (CK1epsilon) and circadian photic responses in hamsters.
Agostino PV et al.
Chronobiology International, 2009
Genetic differences in human circadian clock genes among worldwide populations.
Ciarleglio CM et al.
Journal of Biological Rhythms, 2008
Narcolepsy and familial advanced sleep-phase syndrome: molecular genetics of sleep disorders.
Tafti M et al.
Current Opinion in Genetics & Development, 2007
[Functional polymorphisms in clock genes and circadian rhythm sleep disorders].
Ebisawa T
Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology, 2007
Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes.
Ebisawa T
Journal of Pharmacological Sciences, 2007
Modeling of a human circadian mutation yields insights into clock regulation by PER2.
Xu Y et al.
Cell, 2007
Novel insights from genetic and molecular characterization of the human clock.
Ptácek LJ et al.
Cold Spring Harbor Symposia on Quantitative Biology, 2007
The tau mutation in the Syrian hamster differentially reprograms the circadian clock in the SCN and peripheral tissues.
Dey J et al.
Journal of Biological Rhythms, 2005
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders.
Takano A et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2004
Mutation screening of the human period 2 gene in bipolar disorder.
Shiino Y et al.
Neuroscience Letters, 2003
Casein kinase I: another cog in the circadian clockworks.
Eide EJ et al.
Chronobiology International, 2001
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
Toh KL et al.
Science (new York, N.y.), 2001
Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.
Kovanen L et al.
Alcohol and Alcoholism (oxford, Oxfordshire), 0
Solving the mystery of human sleep schedules one mutation at a time.
Hallows WC et al.
Critical Reviews in Biochemistry and Molecular Biology, 0